Sentences with phrase «on tumor control»

«Canine osteosarcoma treatment focuses on tumor control.

Not exact matches

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

Investigators focused on the tumor suppressor liver kinase B1 (LKB1), a protein that controls cell growth and metabolism.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

His autopsy suggests one troubling explanation: Charles Whitman had a brain tumor pressing on his amygdala, a region of the brain crucial for emotion and behavioral control.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

Researchers have created a new drug delivery system that could improve the effectiveness of an emerging concept in cancer treatment — to dramatically slow and control tumors on a long - term, sustained basis, not necessarily aiming for their complete elimination.

Jantibody focuses the AMD3100 - invigorated immune response on critical tumor structures, markedly enhancing tumor control.

At six months of age, 30 percent of mice on a starch - control diet had measurable tumors, whereas 50 to 58 percent of the mice on sucrose - enriched diets had developed mammary tumors.

Additionally, they examine MMTV - PyMT control or POSTN null mice to test the effect of POSTN on primary tumor growth and metastasis (Figures 3A, 3B, and S13; Malanchi et al., 2012).

LA JOLLA, CA — A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc...

Based on empirical data obtained in cases of chronic myeloid leukemia, a myeloproliferative syndrome controlled by the immune system, and in solid tumors, we observe both the possible contribution of innate CD8 (+) T cells to cancer disease control and their susceptibility to tumor immune subversion.

LA JOLLA, CA — A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc in healthy cells.

With respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune cells).

Because the skull is rigid, providing no room for the tumor to expand, brain tumors may press on parts of the brain that control movement, speech, sight or other vital functions.

Currently, her research interest is focused on the functional characterization of cell - autonomous molecular determinants, known to control cardinal stem cell properties in normal NSCs, in the attempt of understanding their putative role in regulating the same properties in brain tumor - derived cancer stem cells.

Runaway cell proliferation is driven by accelerators, or oncogenes, that are stuck on go — in collusion with broken brakes, or tumor suppressors, that can't control a tumor's pedal - to - the - metal growth.

These results demonstrate the role of a ubiquitin ligase in control of immune checkpoints with concomitant effect on tumor growth.

To explore the biological function of DDX3 on cell growth control, a colony formation assay was done in several tumor cell lines (HuH - 7, HCT116, and HeLa) and normal murine fibroblast cells (NIH 3T3) under the selection of G418.

This integrated team also collaborates to design individualized treatments for each patient, optimizing the patient outcome by maximizing tumor control while minimizing effects on non-tumor tissues.

The targeted drug delivery appears to be a very promising strategy for controlling the biodistribution of the cytotoxic agent only on malignant tissues by linking it to tumor - targeting moiety.

The Vaccine & Immunotherapy Center brings together many outstanding researchers within the Institute to focus on new immune based approaches to induce protective tumor immunity, to control the tumor microenvironment, and to use humoral and cellular immunity to control or eliminate cancer.

Her current focus is on developing clinical protocols for the treatment of head and neck and lung cancers with a goal of providing enhanced tumor control, including control of metastases, with minimal effect of quality of life.

The proliferation rates of the cancer in the flax - eaters were only half that of the controls, confirming the test - tube studies done on prostate cancer cells suggesting that flax can indeed slow prostate tumor growth.

Rats were fed genetically modified corn chow on a daily basis for two years and the results included an exponential increase in mammary tumors, kidney failture and liver necrosis in the rats who ate GMO food compared to their control counterparts.

There are two causes of Cushing» s: a tumor on the adrenal gland or over stimulation of the adrenal glands by the hormones that control them that are regulated by the pituitary glands.

If the tumor is only on one side, the incontinence is typically partial in that the dog has difficulty controlling bowel movements but not continuous dropping of stool.

She arrived from animal control with a horrible mouth, small mammary tumors and a large tumor on her neck.

Willow is a 3 yr old Pomeranian mix from animal control that came to us with heartworms and a serious tumor on her foot.

Therefore, it is critical that the initial treatment be focused on pain control as well as tumor control.

Treatment will ultimately depend on the cause of the veterinarian's findings and could range from medication to control vomiting to treatment for cancer if a tumor is found.

He had a lump removed that was a low grade tumor that was successfully removed and he is on some eye drops to control his glaucoma.

Tumors in the brainstem can be rapidly fatal if, for example, they affect the control of breathing, but typically the first signs of brainstem disease are a loss of balance (vestibular signs), and weakness on one side of the body.