Nebeling LC, Miraldi F, Shurin SB, Lerner E. Effects of a ketogenic diet
on tumor metabolism and nutritional status in pediatric oncology patients: Two case reports.
Not exact matches
Investigators focused
on the
tumor suppressor liver kinase B1 (LKB1), a protein that controls cell growth and
metabolism.
This study of 37 patients (24 men and 13 women, ages 51 to 80) who have never been treated with chemotherapy found direct correlation of the amount of cfDNA with
tumor metabolism (based
on PET - derived parameters), but not with metabolic
tumor volume.
Women who have high levels of both testosterone and estrogen in midlife may face a greater risk of developing benign
tumors on the uterus called uterine fibroids than women with low levels of the hormones, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology &
Metabolism.
«Conversely, the necrotic part of the
tumor is driven by a distinct set of glioma stem cells utilizing the BIM1 pathway and are characterized by a mesenchymal, inflammatory cell type dependent
on glucose
metabolism in the absence of oxygen.
«Our original hypothesis was that cancer cells were modifying their
metabolism based
on communications they were receiving from cells in the microenvironment near the
tumor,» said Nagrath, assistant professor of chemical and biomolecular engineering at Rice and co-author of a new study describing the research in the open - access journal eLife.
«The Metabolic Profile of
Tumors Depends
on Both the Responsible Genetic Lesion and Tissue Type,» by Mariia O. Yuneva et al., Cell
Metabolism, Feb. 8, 2012.
«So a cell that rewires its
metabolism early
on to scarf up nutrients from the environment is more likely to do what the tyrosine kinase pathway sets in motion; it's more likely to have all the things it needs to become a
tumor.»
In 1931 Otto Heinrich Warburg was awarded the Nobel Prize in Physiology for his study
on the
metabolism of
tumors and the respiration of cells, particularly cancer cells.
My objective was to review relevant intervention studies
on the effects of intermittent fasting
on energy balance, cardiovascular risk factors, glucose
metabolism, neurodegenerative pathology,
tumor physiology and life span.
It has been hypothesized that the reported beneficial health effects from caloric restriction
on excess body weight, cardiovascular risk factors, glucose
metabolism,
tumor physiology, neurodegenerative pathology and life span can be mimicked by alternating periods of short term fasting with periods of refeeding, without deliberately altering the total caloric intake.
PubMed between 1973 and 2011 was searched by use of relevant MeSH terms related to the effects of intermittent fasting
on excess body weight, energy balance, aging physiology, cardiovascular risk factors, glucose
metabolism,
tumor physiology and neurodegenerative pathology.
There is data to show that some
tumor types actually can survive and thrive
on ketone
metabolism (1, 2, 3).