Sentences with phrase «on tumor metastasis»
Bernhard Mlecnik and coleagues examin the impact of tumor - intrinsic, microenvironmental, and immunological factors on tumor metastasis in colorectal cancer patients.
http://www.interactive-biosoftware.com/ Not exact matches
The researchers also report that radiation sensitivity may be dependent on the anatomic location of the tumor metastasis.
Last fall, Bergö's group reported that ingestion of extra antioxidants drove the metastasis of melanoma in a mouse model, though they didn't have any effect on the primary tumor.
In an article titled, «Allergen Induced Pulmonary Inflammation Enhances Mammary Tumor Growth and Metastasis: Role of CH13L1,» featured on the cover of the current issue of the Journal of Leukocyte Biology, this new research suggests inflammation raises the level of a known biomarker of cancer, called «chitinase -3-like-1» or «CHI3L1,» in the inflamed tissue, which leads to increased metastasis and faster cancer growth in thMetastasis: Role of CH13L1,» featured on the cover of the current issue of the Journal of Leukocyte Biology, this new research suggests inflammation raises the level of a known biomarker of cancer, called «chitinase -3-like-1» or «CHI3L1,» in the inflamed tissue, which leads to increased metastasis and faster cancer growth in thmetastasis and faster cancer growth in that tissue.
This blood vessel normalization results in an increased barrier function on the one hand — thereby blocking cancer cell dissemination and metastasis - and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.
«If you can get a better handle on the biology of the primary tumor, and the elements of the tumor that may be more or less dangerous, then you don't need to worry about testing every single metastasis for treatment decisions.»
«The result was an extensive inhibition of tumor growth and prevention of metastasis to the lung in HER2 - positive animal models of breast cancer,» notes Navasona Krishnan, Ph.D., a postdoctoral investigator in the Tonks lab who performed many of the experiments and is lead author on the paper reporting the results.
In a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill.
While research has supported AMD3100's ability to inhibit tumor growth and metastasis, the mechanism behind its effects on mesothelioma had not been determined.
Once the tumors are established in the mice, the researchers can introduce additional mutations at any time, allowing them to study the influence of each mutation on tumor initiation, progression, and metastasis.
«Our chip is currently the only device that can potentially capture circulating tumor cells and exosomes directly on the chip, which should increase its ability to detect metastasis.
According to the study's results, the microenvironment of a tumor cell has significant impact on cancer metastasis.
Additionally, they examine MMTV - PyMT control or POSTN null mice to test the effect of POSTN on primary tumor growth and metastasis (Figures 3A, 3B, and S13; Malanchi et al., 2012).
«Based on our findings, the next phase will be to measure exosomes and exomeres in plasma samples to help predict organs that may be targeted for metastasis during tumor progression,» said Dr. Lyden.
The Ludwig Center at the University of Chicago --- under the direction of Ralph Weichselbaum, MD, the Daniel K. Ludwig Professor and Chair of the Department of Radiation and Cellular Oncology, and Geoffrey Greene, PhD, the Daniel K. Ludwig Professor in the Ben May Cancer Research Institute at the University of Chicago — will focus on metastasis, the process by which cancer cells migrate from a primary tumor to multiple distant sites.
Called «tumor microenvironments of metastasis,» these on - ramps are sites on blood vessels that special immune cells flock to.
Perhaps the most intriguing — and contentious — finding of the paper (as highlighted by GT's In Sequence magazine and Keith Robison on Omics Omics) was that few of the somatic mutations in the metastasis were detected in the primary tumor sample from 9 years earlier.
On a brighter note, not all breast cancer patients have the kind of tumor microenvironment in which pre-op chemo can promote metastasis.
What: The Second Edition of the IASLC Staging Manual in Thoracic Oncology reports on the latest revisions of the tumor, node and metastasis (TNM) classifications of thoracic malignancies, namely, lung cancer, malignant pleural mesothelioma, carcinoma of the esophagus and of the esophago - gastric junction and thymic epithelial tumors.
More recently, he has focused on triple - negative breast cancer, the role of micro-RNAs in cancer growth and metastasis, tumor heterogeneity and novel approaches to targeting therapy - resistant breast cancers.
Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).
Discover novel treatments in relapsed pediatric cancer by defining tumor heterogeneity and its effect on self - renewal and metastasis.
5/7/2007 Targeting Sugar on Blood Vessels May Inhibit Cancer Growth In a study that could point to novel therapies to prevent cancer spread, or metastasis, researchers at the University of California, San Diego (UCSD) School of Medicine have targeted a sugar that supports blood vessel growth in the tumor.
The correlations between DAXX and DAPK1 / 3 expression will be based on the tumor grade, stage, and disease metastasis.
These tumors have about a 20 - 25 % chance for metastasis in general, but the metastatic potential for each individual tumor will vary depending on its grade.
The course of treatment should be decided based on the size of the tumor, the stage of the disease and the extent of metastasis.
Treatment depends on the location of the tumor and whether there has been metastasis at the time of diagnosis.
Prognosis of patients with this disease depends on multiple factors, the most commonly cited including: presence of metastasis (negative), elevated alkaline phosphatase (negative), large tumor size (negative), humerus location (negative), treatment chosen (dogs receiving amputation and chemotherapy have improved survival times over dogs receiving amputation alone) 1.
The outcome for patients with malignant mammary gland tumors depends on several factors including tumor type, histologic grade (appearance of the tumor cells under the microscope and how similar or dissimilar they are to normal tissues), tumor size, and tumor stage (presence of regional and distant metastasis).