Sentences with phrase «on tumor samples»

Zhang et al performed whole - genome sequencing on tumor samples and matched normals from 12 children with ETP - ALL.

Not exact matches

For example, TCGA, with genomic data on 33 tumor types taken from samples from 11,000 patients, is finishing 2018 by publishing a series of papers and holding a symposium.

Many tumors release cells with distinctive antigens on their surfaces, and affinity - based techniques can pull these cells out of the blood sample relatively easily.

Zhang's group is moving beyond bulk sequencing of tumor samples and is now conducting genomics on single cells.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

In blood samples from 1005 patients with eight types of tumors that had evidently not yet metastasized, the test detected between 33 % and 98 % of cases, depending on the tumor type (see graph, above).

«This gives us novel and exciting new therapeutic options to pursue based on results from drug screenings of primary tumor samples from patients.»

The finding, reported by a Stand Up to Cancer - Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking therapy.

Caris performed the molecular profiling on 48,733 solid tumor samples to assess the prevalence of homologous recombination deficiency in about 20 different types of solid tumors.

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

«The enhancing effect was not seen in a patient tumor sample with a low level of NRP - 1 expression on the vasculature.

Capture experiments were also performed on whole blood samples, and the capture efficiency was in a high range of 81 - 95 %, at different tumor cell concentrations.

The researchers were able to replicate this finding by comparing the healthy thyroid tissues in GTEx to 500 samples taken from thyroid tumors, compiled by The Cancer Genome Atlas, and giving support to the extensive impact of FOXE1 on cellular state.

The total environmental DNA of grape crown gall tumor disease is revealed in the genetic profile based on 52 tissue samples of crown gall tumor taken from 16 grapevine species.

Working in mouse models of breast cancer and breast tumor samples from patients, Longmore and his colleagues showed that a protein that sits on the surface of tumor cells, called DDR2, binds to collagen and activates a multistep pathway that encourages tumor cells to spread.

Researchers also can't draw inferences from a single sample on the frequency of tumors in the Neandertal population, he says.

In the first cohort, researchers led by Jeeyun Lee, MD, from Sungkyunkwan University School of Medicine in Seoul, performed whole exome sequencing on samples from paired synchronous primary and metastatic tumors.

The project would also save money by gathering tumor samples from completed clinical trials and observational studies, as well as by piggybacking on planned studies.

«Based on our findings, the next phase will be to measure exosomes and exomeres in plasma samples to help predict organs that may be targeted for metastasis during tumor progression,» said Dr. Lyden.

The initial version of CRI iAtlas is based on an analysis performed by The Cancer Genome Atlas (TCGA) Research Network on the TCGA data set comprising over 10,000 tumor samples and 33 tumor samples (Thorsson et al..

Perhaps the most intriguing — and contentious — finding of the paper (as highlighted by GT's In Sequence magazine and Keith Robison on Omics Omics) was that few of the somatic mutations in the metastasis were detected in the primary tumor sample from 9 years earlier.

The company has labs around the world, from London to Israel to Singapore, to reduce the amount of time a given tumor sample spends on a plane, for example.

The scientists extensively studied 28 tumor samples from children with medulloblastoma, surveying each tumor for details about how its genes are turned on and off.

In close collaboration with oncologists at the Olivia Newton John Cancer Research Institute (ONJCRI), the technology was tested on blood samples from melanoma patients and was able to track critical changes in spreading tumor cells before, during and after treatment.

The study focused on just one exhaustively sampled tumor, but it raises important questions.

For example, the goal of the drug response challenge is to predict how a tumor will respond to a drug based on the characteristics of both the tumor and the drug, the information for which is identified through previously available data, such as tumor samples and previous drug screens.

He has also been leading statistical data analysis for the Broad Institute's Proteome Characterization Center and Proteogenomic Data Analysis Center established under the National Cancer Institute Clinical Proteomics Tumor Analysis Consortium (CPTAC), focusing on proteogenomic analysis of proteomic, phosphoproteomic, and genomic data derived from cancer samples.

Targeted sequencing was performed on available tumor samples of 125 patients.

Caris, under the guidance of Baker, provided the tissue and ran the molecular profiling on solid tumor samples collected from across the United States.

Because of small sample size, the changes in tumor - initiating cell number were not significant (P > 0.05), but these data are supportive of the in vitro findings and suggest that hypoxia may have a positive effect on the tumor - initiating cell population in ER - α — positive breast cancers and a negative effect in ER - α — negative tumors.

Since completing the initial paper published Thursday, the team has analyzed 50 more samples from eye fluid of retinoblastoma patients, including those with less aggressive tumors whose eyes were saved, to get a start on determining what factors might be at play in tumor progression.

When the researchers sequenced the samples for genetic mutations and analyzed chromosome structure, they could trace the tumors» evolutionary histories, much as evolutionary biologists trace the origins of organisms back to their common ancestors based on fossils deposited in different geologic eras.

After a sample was taken from the patient on the left (or top for those on their mobile devices) and sent out to a laboratory for analysis, the mass was indeed diagnosed as a lipoma (benign fat cell tumor).

The diagnosis, prediction of behavior (prognosis) and a microscopic assessment of whether the tumor has been completely removed rely on microscopic examination of tissue samples (histopathology).

Accurate diagnosis, prediction of behavior (prognosis) and a microscopic assessment of whether the tumor has been fully removed rely on microscopic examination of tissue samples (histopathology).

A biopsy is very different from a needle sample of a tumor (fine - needle aspirate), where cells are drawn out with a needle and placed on a slide to be examined under a microscope.

The diagnosis is made based on history, x-rays of the bone and ultimately a biopsy, or removal of a tissue sample from the tumor.

The histopathology report will include information on the type and grade of tumor (the type of cells and their degree of resemblance to normal cells), how it is likely to behave (the prognosis) and whether, if the sample represented an excision biopsy, the cancer has been fully removed.

A cystoscope is a long, thin, tube - shaped instrument with a camera on the end of it, which is used to nonsurgically obtain biopsy samples from tumors inside the bladder and urethra.

A specific tumor type can be suspected from its appearance on a CT or MRI, but can only be definitively identified by taking a sample of the tumor, either at surgery or by biopsy.

They also found that just over half the tumors samples analyzed carry genetic mutations that could be targeted by therapies that are already on the market.