Sentences with phrase «on tumor suppressor»

To figure out the mechanism by which apple peels cleaned cancer's clock, the researchers measured the effect of apple peels on the tumor suppressor protein maspin inside the cancer cells.

Inhibition of transcription (blockade of water) on tumor suppressor genes, such as p21, leads to cell transformation (growth of the cactus - like eremophytes instead of normal plants from the drought).

Related sites Hakem and colleagues» Science paper Razqallah Hakem's home page Background on some tumor suppressor genes

Investigators focused on the tumor suppressor liver kinase B1 (LKB1), a protein that controls cell growth and metabolism.

Not exact matches

African - Americans, on the other hand, experienced heightened mutations in BCL7A, a different tumor suppressor gene.

On the other hand, our earlier work also showed that this enzyme acts to silence tumor - suppressor genes.

But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been described as an oncogene that promotes cancer because it was believed to inactivate the Rb tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.

«Our data strongly suggest that KIF1Bβ, which is localized on chromosome 1p36, might be such a neuroblastoma tumor suppressor gene,» says principal investigator Susanne Schlisio at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet and Assistant Member at the Ludwig Institute for Cancer Research in Stockholm, Swtumor suppressor gene,» says principal investigator Susanne Schlisio at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet and Assistant Member at the Ludwig Institute for Cancer Research in Stockholm, SwTumor and Cell Biology at Karolinska Institutet and Assistant Member at the Ludwig Institute for Cancer Research in Stockholm, Sweden.

Sometimes oncogenes manage to initiate tumor development in the presence of p53, but, even then, the tumor suppressor doesn't give up and focuses its efforts instead on limiting the tumor's ability to invade and metastasize.

«These findings show that miR - 486 serves a tumor - suppressor function in lung cancer, and that miR - 486 action is partially dependent on p53.»

Among them: some genes believed to be tumor suppressors turned on or became more active, whereas certain disease - promoting ones, including oncogenes (in the so - called RAS family that are implicated in both prostate and breast cancer), were down - regulated or switched off.

In a retrospective case study involving published data on p53, an important tumor suppressor protein, the team showed that this new resource called the Knowledge Integration Toolkit (KnIT) is an important first step in that direction, accurately predicting the existence of proteins that modify p53 — proteins that were subsequently found to do just that.

In the first test using KnIT, the team sought to identify new protein kinases that phosphorylate (or turn on) the protein tumor suppressor p53.

A significant finding by the team was that either the mutant KRAS gene or another cancer gene is amplified, depending on which tumor suppressor gene is affected and to what degree its function is impaired.

Another key finding was observing the inhibitor effect on tumor models with a gene PTEN deficiency as a biomarker — of huge interest because PTEN, a tumor suppressor, is known to be defective in as many as half of all advanced solid tumor cancers.

The scientists are planning further study of HOXA5's role in breast cancer, following up on this work and a study published by Sukumar's lab in 2000 that showed a connection between low levels of HOXA5 and the well - known tumor suppressor protein p53.

To turn malignant, a tumor must evolve with at least one oncogene jammed in the «on» position and at least one tumor - suppressor gene jammed in the «off» position.

They generated a list of suspected oncogenes and tumor suppressor genes based on their mutation patterns — and found many more potential cancer drivers than anticipated.

On the other hand, aberrant expression of miR - 7 was observed in glioblastomas, and it has been characterized as a putative tumor suppressor by targeting EGFR and AKT (23, 24).

Within this cascade Shp2 turns on different signaling molecules, but turns off the tumor suppressor genes p27 und p53.

LA JOLLA, CA — A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc...

La Jolla, CA — The cellular cascade of molecular signals that instructs cells with fatally damaged DNA to self - destruct pivots on the p53 tumor suppressor gene.

LA JOLLA, CA — A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc in healthy cells.

Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.

As a powerful tumor suppressor, p53 turns on genes that either halt cell division to allow time for repair of damaged DNA or, when all rescue attempts prove futile, to prevent cells with genetic defects from dividing, as this would fuel the development of cancer.

Preferential glycolysis has been associated with activated oncogenes and loss of tumor suppressors, both of which confer other hallmark capabilities on cancer cells.

His team identified a factor that may be important for clinical trial design: progesterone was not toxic to all glioblastoma cell lines, and its toxicity may depend on whether the tumor suppressor gene p53 is mutated.

Runaway cell proliferation is driven by accelerators, or oncogenes, that are stuck on go — in collusion with broken brakes, or tumor suppressors, that can't control a tumor's pedal - to - the - metal growth.

Congratulations to SCAHT research group leader Prof. Luigi Terracciano and other collaborators of Prof. Michael N Hall at the University of Basel on their recent Nature publication describing the discovery of protein LHPP as a key tumor suppressor...

Cancer can also occur when certain normal genes (tumor suppressor genes, for example) are «switched on or off» as a result of environmental epigenetics — influences that occur throughout your life.

During his 11 years of extensive work experience in the fields of cell and cancer biology (including work on the famous tumor suppressor gene BRCA1), and biochemistry he has successfully published in peer - reviewed journals such as Molecular and Cell Biology and Cancer Research.

His growth - regulation research is now focused primarily on the DLC family of tumor suppressor genes and their mechanism of action.

4/9/2007 UCSD Researchers Discover Variants of Natural Tumor Suppressor Finding could lead to therapy targets for diabetes, heart disease and cancer Building on their 2005 discovery of an enzyme that is a natural tumor suppressor, researchers at the University of California, San Diego (UCSD) School of Medicine have now... MoTumor Suppressor Finding could lead to therapy targets for diabetes, heart disease and cancer Building on their 2005 discovery of an enzyme that is a natural tumor suppressor, researchers at the University of California, San Diego (UCSD) School of Medicine have now.Suppressor Finding could lead to therapy targets for diabetes, heart disease and cancer Building on their 2005 discovery of an enzyme that is a natural tumor suppressor, researchers at the University of California, San Diego (UCSD) School of Medicine have now... Motumor suppressor, researchers at the University of California, San Diego (UCSD) School of Medicine have now.suppressor, researchers at the University of California, San Diego (UCSD) School of Medicine have now... More...

Wilms» tumor is a childhood kidney cancer caused by the loss or inactivation of a tumor suppressor gene called QT1 on chromosome 11.

Tumor - suppressor connects with histone protein to hinder gene expression (4/10/2014) Dr. Hong Wen, an Assistant Professor in Xiaobing Shi's lab found that the protein ZMYND11 recognizes a special mark on another protein that helps package and protect DNA, the histone variant H3.3.

Faulty tumor suppressor genes, on the other hand, fail to carry out these functions and give rise to faulty cells that can grow uncontrollably and cause cancer.

But a puzzle remains: if a drug wipes away methylation indiscriminately, that might turn on an oncogene just as much as it might restore a tumor suppressor gene.

These suppressor genes are inactivated in tumors, and since cancer drugs work by reducing the activity of enzymes, they won't work on such suppressors because a drug can't inhibit a gene that is already inactivated.»

On the one hand, autophagy functions as a tumor suppressor mechanism by preventing the accumulation of damaged organelles and aggregated proteins.

The pro-survival effects of SIRT1 may promote cancers, but on the other hand, it also clearly functions as a tumor suppressor.