Sentences with phrase «on tumor suppressor genes»

Inhibition of transcription (blockade of water) on tumor suppressor genes, such as p21, leads to cell transformation (growth of the cactus - like eremophytes instead of normal plants from the drought).

Related sites Hakem and colleagues» Science paper Razqallah Hakem's home page Background on some tumor suppressor genes

Not exact matches

African - Americans, on the other hand, experienced heightened mutations in BCL7A, a different tumor suppressor gene.

On the other hand, our earlier work also showed that this enzyme acts to silence tumor - suppressor genes.

«Our data strongly suggest that KIF1Bβ, which is localized on chromosome 1p36, might be such a neuroblastoma tumor suppressor gene,» says principal investigator Susanne Schlisio at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet and Assistant Member at the Ludwig Institute for Cancer Research in Stockholm, Swtumor suppressor gene,» says principal investigator Susanne Schlisio at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet and Assistant Member at the Ludwig Institute for Cancer Research in Stockholm, SwTumor and Cell Biology at Karolinska Institutet and Assistant Member at the Ludwig Institute for Cancer Research in Stockholm, Sweden.

Among them: some genes believed to be tumor suppressors turned on or became more active, whereas certain disease - promoting ones, including oncogenes (in the so - called RAS family that are implicated in both prostate and breast cancer), were down - regulated or switched off.

A significant finding by the team was that either the mutant KRAS gene or another cancer gene is amplified, depending on which tumor suppressor gene is affected and to what degree its function is impaired.

Another key finding was observing the inhibitor effect on tumor models with a gene PTEN deficiency as a biomarker — of huge interest because PTEN, a tumor suppressor, is known to be defective in as many as half of all advanced solid tumor cancers.

To turn malignant, a tumor must evolve with at least one oncogene jammed in the «on» position and at least one tumor - suppressor gene jammed in the «off» position.

They generated a list of suspected oncogenes and tumor suppressor genes based on their mutation patterns — and found many more potential cancer drivers than anticipated.

Within this cascade Shp2 turns on different signaling molecules, but turns off the tumor suppressor genes p27 und p53.

La Jolla, CA — The cellular cascade of molecular signals that instructs cells with fatally damaged DNA to self - destruct pivots on the p53 tumor suppressor gene.

As a powerful tumor suppressor, p53 turns on genes that either halt cell division to allow time for repair of damaged DNA or, when all rescue attempts prove futile, to prevent cells with genetic defects from dividing, as this would fuel the development of cancer.

His team identified a factor that may be important for clinical trial design: progesterone was not toxic to all glioblastoma cell lines, and its toxicity may depend on whether the tumor suppressor gene p53 is mutated.

Cancer can also occur when certain normal genes (tumor suppressor genes, for example) are «switched on or off» as a result of environmental epigenetics — influences that occur throughout your life.

During his 11 years of extensive work experience in the fields of cell and cancer biology (including work on the famous tumor suppressor gene BRCA1), and biochemistry he has successfully published in peer - reviewed journals such as Molecular and Cell Biology and Cancer Research.

His growth - regulation research is now focused primarily on the DLC family of tumor suppressor genes and their mechanism of action.

Wilms» tumor is a childhood kidney cancer caused by the loss or inactivation of a tumor suppressor gene called QT1 on chromosome 11.

Tumor - suppressor connects with histone protein to hinder gene expression (4/10/2014) Dr. Hong Wen, an Assistant Professor in Xiaobing Shi's lab found that the protein ZMYND11 recognizes a special mark on another protein that helps package and protect DNA, the histone variant H3.3.

Faulty tumor suppressor genes, on the other hand, fail to carry out these functions and give rise to faulty cells that can grow uncontrollably and cause cancer.

But a puzzle remains: if a drug wipes away methylation indiscriminately, that might turn on an oncogene just as much as it might restore a tumor suppressor gene.

These suppressor genes are inactivated in tumors, and since cancer drugs work by reducing the activity of enzymes, they won't work on such suppressors because a drug can't inhibit a gene that is already inactivated.»