Sentences with phrase «on tumorigenesis»

In preclinical trials, the effect of chloroquine and hydroxychloroquine on tumorigenesis has been extensively investigated in mouse cancer models, including genetic and xenograft models (summarized in Table 2).

«As bioengineers, we can now design 3D culture systems where environmental parameters such as composition, porosity, and stiffness can be precisely tuned to study the importance of these cues on tumorigenesis,» says coauthor Sandeep Koshy, a Harvard graduate student in the Harvard - MIT Program in Health Sciences and Technology, who works in Mooney's lab at Harvard SEAS and at the Wyss Institute for Biologically Inspired Engineering.

Not exact matches

Smoothened (Smo) is a 7TMR that mediates effects of Hedgehog on developmental processes and whose dysregulation may cause tumorigenesis.

«Our results suggest that intentional body weight loss by diet manipulation does not provide any beneficial effects on colon tumorigenesis and it may in fact aggravate liver capacity of repair.»

As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).

Their findings, «Initiation of Inflammatory Tumorigenesis by CTLA4 Insufficiency Due to Type 2 Cytokines,» were published online on January 26 by the Journal of Experimental Medicine.

On the basis of this, we have hypothesized that p21 - deficient mice should not have an increased susceptibility to radiation - induced tumorigenesis.

Cancer studies have increasingly focused on chromatin — the intertwined proteins and DNA that are packaged into chromosomes — because of its ability to regulate genes important for either activating or inhibiting tumorigenesis.

As reported this month in Nature, the in vivo screen focused on 133 metabolic genes that the researchers predicted to be necessary for tumorigenesis.

Using Plk4 overexpression (PLK4OE) during epidermal development, we assess the impact of centrosome amplification and aneuploidy on skin development and tumorigenesis.

Dr. Harris is a renowned expert on the role of COX - 2 in chronic inflammation and in promoting tumorigenesis and angiogenesis, and has authored numerous papers in peer - reviewed journals and book chapters on the use of NSAIDS and selective COX - 2 inhibitors in the chemoprevention of various cancer types.

The «Meet Our Scientists» video entitled «Our relative the fly» presents the research performed by Marco Millán on the cellular and molecular mechanisms underlying the regulation of tissue growth during normal development, tissue homeostasis, and tumorigenesis.

Dr. Charron's research focuses on understanding how medulloblastoma forms, in particular which genes may promote or inhibit medulloblastoma tumorigenesis.

Estrogens are known for their proliferative effects on estrogen - sensitive tissues resulting in tumorigenesis.