Sentences with phrase «on tumour cells»

The same thing happens (the inhibition of stated growth factors) with hyperbaric oxygen therapy so it makes sense how all this fits together in powerful synergy to increase metabolic stress on tumour cells.

Most of the studies have focused mainly on tumour cells, whilst the cells that form the stroma are the great unknown, in spite of different research groups proving that some components of stroma promote the tumour progression.

Not exact matches

And a histogram of stiffness showed that as tumours become «pre-malignant», two peaks appear on the graph, rather than the single one observed for normal cells.

Researchers at the University of Gothenburg are focusing on how HAMLET can be taken up into tumour cells.

Although these spots themselves are harmless, if some of the spots are bigger than a 50 cent coin, then it could be due to Neurofibromatosis (NF), which is a genetic disorder of the nervous system that causes abnormal cell growth of nerve tissues or benign tumours to form on the nerves anywhere in the body at any time.

To target liposomes to certain tissues or cells, such as tumour cells, a specific binder of a unique protein (an antigen) on the targeted cell, known as a monoclonal antibody, must be linked to the liposome surface.

«Myeloid - derived suppressor cells (MDSCs) produce reactive nitrogen radicals that alter the receptors on the surface of the tumour to hide it from cytotoxic lymphocytes that kill tumour cells.

Only cancer cells that received these growth factors switched on this pathway, and only they could seed new tumours when injected into mice.

«We would hope to create little protein factories in the tumour cell that are only switched on when the cells are hypoxic,» says Kingsman.

Now, the researchers have discovered an alternative in a mouse model: in the case of breast tumours with a specific defect in DNA repair, the animals can be cured using already established, cheap chemotherapy drugs, if enough DNA damage can be inflicted on the resting tumour cells.

When The Cancer Genome Atlas Research Network reported its genomic profiling of clear - cell kidney tumours, about one - quarter of participants (126 patients) had been operated on at Memorial Sloan Kettering3.

Growing mini tumours in the lab from a patient's own cells could help doctors discover the best way to treat each person, homing in on the right drugs to use

Lead author Moustafa Abdalla writes: «Almost all genomic studies of breast cancer have focused on well - established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells.»

The team used five types of antibiotics — including one used to treat acne (doxycycline)-- on cell lines of eight different types of tumour and found that four of them eradicated the cancer stem cells in every test.

New research on bowel cancer has shown that every tumour is different, and that every cell within the tumour is also genetically unique.

The team worked on tissue from three patients with colorectal cancer, taking normal bowel stem cells and cells from four different areas of the tumours.

To carry out the study, the team has analysed how different carbohydrates act on the surface of silver nanoparticles (Ag - NP) of around 50 nanometres, which have been introduced into cultures of liver cells and tumour cells from the nervous system of mice.

The discovery could pave the way for new treatments that are able to block cell signals switched on in tumours with low levels of PTEN.

The study, funded by the charity Brain Tumour Research and conducted by researchers at their UK Centre of Excellence at the University of Portsmouth, examined the factors present on the surface of NSCLC cells.

Ovarian cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high - grade serous ovarian cancer, the most common and lethal subtype of the disease.

While it is present on a number of different types of cells in the body, it is expressed at higher levels on metastatic tumour cells, including those which have spread from the lung.

It could have implications for HIV patients, both with and without cancer, as it can work on HIV reservoirs and tumour cells independently.

Therefore, researchers from the CNIO's Experimental Oncology Group have focused their work on identifying a stromal cell population that fosters tumour growth, to later discover why they have this capacity and reverse it.

Research fields are diverse, including basic research on cell proliferation, analysis of tumour cells and tissues to detect gene mutations, and identification of potential therapeutic targets in cancer.

Haotian Zhao, Ph.D., is the lead author on the study titled «Sonic Hedgehog promotes proliferation of Notch - dependent monociliated choroid plexus tumour cells.»

There is a danger that the Adriamycin would only get to the cells in the centre of the tumour, and fail to reach cells on the periphery, he believes.

Olaparib stopped prostate cancer growth, generating falls in prostate specific antigen (PSA) levels, falls in circulating tumour cell counts in the blood, and radiological responses on CT scans and MRI.

The study, which is published in the journal Nature Communications, was conducted on human tumour cells and on mice, and offers hope of a much improved therapy for a severe form of cancer.

After injecting them into the bloodstream, we are able to gather them around the tumour using magnets and ensure that they don't kill the healthy cells,» explains Asst Prof Xu, who has been working on cancer diagnosis and drug delivery systems since 2004.

«Our research focuses particularly on the activity of this gene and how it relates to neuroblastoma,» says Professor Marie Arsenian - Henriksson at the Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet.

Mutations in a gene that helps regulate when genes are switched on and off in cells have been found to cause rare cases of Wilms tumour, the most common kidney cancer occurring in children.

This helps to ensure that the drugs can reach the cancer cells on the surface and also inside the core of the tumour.»

Kasid said: «If the cells are targeted to the tumour, what additional effects would release of cytokines locally have on the tumour?»

For example, a gene called p53, which normally acts as a brake on cell division, turns out to be mutated or lost in about half of all tumours.

Dr Claus Jorgensen, who led the research at The Institute of Cancer Research, London, and at Cancer Research UK's Manchester Institute at the University of Manchester, said: «The next step is to figure out how to keep this receptor switched on, so that the tumour cells can't leave the blood vessels — stopping breast cancer spreading and making the disease easier to treat successfully.»

Carried out in cells in the laboratory, in mice and in samples from patients» tumours, the researchers showed this «safe haven» lets melanoma cells turn on a parallel set of cell signals that helps them survive.

The tumour killing functions of Natural Killer cells require energy and to meet this demand NK cells take on more fuel, which they burn within a metabolic engine to drive energy production.

*** It is directed against the 5T4 / WAIF1 tumour antigen, a protein found on many different solid tumours and is thought to contribute to the spread of cancer cells.

As seen with pseudo-coloured scanning electron microscopy, two cell - killing T - cells (red) attack a squamous mouth cancer cell (white) after a patient received a vaccine containing antigens identified on the tumour.

We target tumours by exploring how the proteins found on the cancer cell surface can be utilised to inhibit growth or kill tumours.

We initially focused on drilling down into the genetic differences between glioblastoma tumour stem cells and normal neural stem cells.

«We showed that there are markers on these stomach tumour cells that indicate they would be responsive to a type of immunotherapy called immune checkpoint inhibitors, in particular anti-PDL1 immunotherapy, which is already used with great success in the treatment of melanoma and certain other cancers.

Both men and women were less likely to survive if their tumour cells had switched on the genes associated with consuming sugar, or glycolysis.

The meeting will also feature other aspects of the Human Cell Atlas initiative, including updates on progress so far towards atlases of tumour, lung, gut, kidney and immune system cells.

No study contained data on the effect of quitting smoking on cancer specific mortality or on development of a second primary tumour in non-small cell lung cancer.

Because tumour cells are more dependent than their normal neighbours on accelerated nutrient import, these up - regulated transporters could be excellent targets for selective anti-cancer therapies.

Kelley, lead investigator on the study published today in Nature Chemistry, explained how her team has advanced a completely new approach using magnetic nanoparticles with DNA capture probes on their surface that can target circulating tumour cells (CTCs) in blood samples to see if the cells contains biomarkers associated with drug resistance.

When normal cells turn into tumour cells, some of the antigens on their surface change.

On the basis of studies on the XMRV - producing human prostate cancer cell lines CWR22Rν1 and CWR - R1 and their progenitor tumour xenograft CRW22, they concluded that XMRV infections were caused by contamination during in vivo passaging in nude micOn the basis of studies on the XMRV - producing human prostate cancer cell lines CWR22Rν1 and CWR - R1 and their progenitor tumour xenograft CRW22, they concluded that XMRV infections were caused by contamination during in vivo passaging in nude micon the XMRV - producing human prostate cancer cell lines CWR22Rν1 and CWR - R1 and their progenitor tumour xenograft CRW22, they concluded that XMRV infections were caused by contamination during in vivo passaging in nude mice.

Areas of focus include: understanding how tumour - reactive T cells and B cells promote patient survival in cancer; defining the effects of standard treatments on tumor immunity; and using genomic approaches to identify novel tumour mutations that can serve as target antigens for immunotherapy.