Not exact matches
Given their in vivo role in pathogenicity, and based
on the yeast two - hybrid interaction data, these results point to the importance of these pathogen proteins in modulating host
ubiquitination pathways, phagosomal escape, and actin - cytoskeleton rearrangement processes.
On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting
ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Analysis was carried out using purified c - ABL and the substrate peptide, EAIYAAPFAKKK, in association with the MRC Unit
on Phosphorylation and
Ubiquitination, University of Dundee, Scotland.