Sentences with phrase «on vertebrate genome»
The performance of our workflow was assessed on vertebrate genome assemblies of various qualities (platypus, pig, horse, dog, mouse and human).
https://www.sciencedaily.com/ Not exact matches
Unlike the previous studies that focused on certain species or a particular RNA virus, Skalka went broad: She and her colleagues surveyed every vertebrate genome available, 48 in all, and looked for hints of 5666 RNA viral sequences from 38 known families and nine genera that were unclassified.
«Vertebrate genomes are typically on the larger side, so it takes a lot of computational power to assemble them,» says Card.
For most vertebrates it's not immediately apparent why genome deletions and add - ons typically go hand - in - hand.
To study evolution across a major vertebrate class, dissect the genomics of complex traits, and resolve a centuries - old debate on the avian species tree, we formed a consortium focused on the sequencing and analyses of at least one genome per avian order.
«Our study reveals a spectrum of methods that nature uses to allow organisms to adapt to different environments,» said senior author Kerstin Lindblad - Toh, Scientific Director of Vertebrate Genome Biology at the Broad Institute: «These mechanisms are likely to be also at work in humans and other vertebrates, and by focusing on the remarkably diverse cichlid fishes, we were able to study this process on a broad scale for the first time.»
Toward this end, we focused on a medically relevant 2.6 - Mb region of the human chromosome Xp11.4 between markers DXS9851 and DXS9751 and identified 16 transcription units according to the Vertebrate Genome Annotation (Vega) rules.
Among vertebrates, the fish model displays easy high density breeding (short generation time), favourable biological peculiarities (accessibility and transparency of the eggs, genome sequenced for both species used on the platform), original technological approaches (confocal and two - photon microscopy), as well as a wide accessibility to fully transparent larvae usable up to 5 days after fertilization.
The phylogenetic position of the cephalochordate amphioxus, together with its relatively simple and evolutionarily conserved morphology and genome structure, has led to its use as a model for studies of animal evolution, with a special focus on the origin of deuterostomes, chordates, and vertebrates.
«Our study reveals a spectrum of methods that nature uses to allow organisms to adapt to different environments,» said co-senior author Kerstin Lindblad - Toh, Co-Director of SciLifeLab, scientific director of vertebrate genome biology at the Broad Institute and professor in comparative genomics at Uppsala University «These mechanisms are likely also at work in humans and other vertebrates, and by focusing on the remarkably diverse cichlid fishes, we were able to study this process on a broad scale for the first time.»
Altogether, the data presented in this study reinforces the evolutionary importance of the two rounds of whole genome duplication that occurred in the vertebrate ancestor and sheds light on the differential behaviour of gene duplicates that arose in these events.
On September 1st, 2015 we received a curt response from Michele Koltookian, Sample Coordinator, Vertebrate Genome Biology, The Broad Institute of Harvard and MIT.