Sentences with phrase «on white blood cells»

Researchers focused on white blood cells called macrophages that work to destroy invading bacterial microbes.

The work focused on white blood cells called regulatory T cells.

Antigens that appear on white blood cells as well as cells of almost all other tissues.

The telomeres on her white blood cells were also drastically worn down.

On average, the telomeres on the white blood cells were 17 times shorter than those on brain cells, which hardly replicate at all throughout life.

«Our data clearly showed that one of the protein receptors on white blood cells called CXCR3 brings white blood cells to the optic nerve in response to production of its binding partner CXCL10 by damaged nerve tissue,» said Zhang.

Pediatric immunologists Gurjit Khurana Hershey and Talal Chatila of the Washington University School of Medicine in St. Louis and their colleagues set out to examine the receptor protein that IL - 4 binds to on white blood cells.

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

Rubinstein said checkpoint therapies work by cutting the brake cables on the white bloods cells that are inherently able to kill tumor cells.

Most importantly, the doxorubicin - decorated diamonds had no effect on white blood cell count, an indicator of immune system activation that's often the deciding factor in whether a patient can continue chemotherapy.

Not exact matches

The old episode on the immune system took us into the blood vessels and showed us the drama of white blood cells marking strep bacteria for death, then engulfing and digesting them.

As for this breathtakingly moronic blithe assumption that the risk of infection is «* probably *» just as high with the benefit of a protective covering, smegma, and white blood cells as with an open wound on a mucus membrane being thrust into constant contact with urine and feces?

White blood cell levels are elevated after birth, but slowly fall as time goes on.

This elusive stability must be achieved before stem cell supplies can be kept on hand until it is time to turn them into replacements for say misshapen red blood cells seen in sickle cell anemia or abnormal white blood cells causing leukemia.

The team tested the technique on cells in culture that mimic the transformation of unspecialised white blood cells into full immune cells.

Based on what is already known about fostamatinib toxicity, Shih says that patients using a combination of fostamatinib and paclitaxel may experience side effects that include low white blood cell counts, nausea, vomiting and diarrhea.

Somewhere, they mused, a mosquito that fed on a dinosaur might be trapped in amber, and white blood cells from the dinosaur might be preserved in the mosquito's stomach.

The study, recently published in Cell Metabolism, also found that beige fat, unlike the better - known white and brown fat, has interesting anti-diabetic effects on blood sugar metabolism that seem independent of temperature regulation.

This is how treatments based on a type of white blood cell called T - cells are curing some cancers, rather than just slowing their advance (see «Cancer meets its nemesis in reprogrammed blood cells «-RRB-.

There is also some evidence that repeated bouts of intense exercise on consecutive days can lead to white blood cell death or dysfunction.

«Tumor cells often produce suppressive factors which essentially turn the brakes on tumor - killing white blood cells.

They specifically studied the length of telomeres (repeated DNA sequences) on the ends of chromosomes in leukocytes (white blood cells); the protective caps are believed to be markers of biological aging, because they shrink over time.

By analyzing chemical changes of the IRS - 2 protein in immortalized cultures of human white blood cells, it determined that IRS - 2 appeared in two different forms — «on,» which allows the signal to pass through, and «off,» which stops the signal from activating the cells into M2 macrophages.

The first - ever study of radiation exposure on wild primates, conducted in 2012, found that monkeys near Fukushima had significantly lower red and white blood - cell counts compared with monkeys elsewhere in Japan.

And the cells in our body differ from one another — serving as neurons, white blood cells, smell sensors, and so on — largely because they activate different sets of genes and thus produce different mixtures of proteins.

Yonju Ha, a lead author of this article, said that further studies on this receptor and its role in white blood cell recruitment following tissue injury may aid in the development of new interventions for diseases associated with nerve injury, such as TON, stroke, diabetic retinopathy and glaucoma.

Chronic myeloid leukemia (CML) is a form of blood cancer based on a genetic disorder that leads to the overproduction of white blood cells.

With his colleague Dr. Van Trung Chu, Graf tested the system on certain white blood cells in the mouse, the B cells.

Kipnis and his colleagues had previously shown that a type of white blood cell called a T cell (shown above) in the meninges is associated with significant influence on cognition and hence were curious about the role of meningeal immunity on brain function.

When looking for culprits, researchers have often focused their microscopes on macrophages, which occupy a meaningful spot among the white blood cells in the tumor microenvironment.

The bile acids accumulate in the blood and interact with the TGR5 receptor on white fat cells to change their metabolic function.

The biochemical on - off switch for asthma lurks within what are called T - helper cells, specialized white blood cells that marshal other kinds of T cells to combat invaders.

They've even injected white blood cells into the vessels and watched as they squeezed through gaps in the vessel wall to reach the tissue on the other side, just as they do in the human body.

Doherty and Zinkernagel discovered that white blood cells must identify simultaneously a viral invader and proteins on the body's own immune cells.

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

After five years, the telomeres on a type of white blood cell were 10 per cent longer on average in these men.

The system is based on the Appendicitis Inflammatory Response (AIR) score, which includes the following parameters: pain in right iliac fossa, history of vomiting, rebound tenderness or muscular guarding, body temperature, white blood cell count, proportion of neutrophil granulocytes, and C - reactive protein concentration.

In light - sheet mode, they clearly saw the 3D dynamic nature of tiny protrusions on living white blood cells when they acquired 150 triple - view images over 40 minutes.

They focused on a prominent type of white blood cells: lymphocytes.

In this case, both teams designed their antibodies to clasp an HIV protein and CD3, a receptor found on the surface of white blood cells.

Approximately 1 percent of Caucasians lack a protein called CCR5 on their CD4 T cells — the white blood cells that normally kill invaders but that harbor HIV.

The other evidence for the stem cell fatigue came from observations that van Andel - Schipper's white blood cells had drastically worn - down telomeres — the protective tips on chromosomes that burn down like wicks each time a cell divides.

When they realised that E-selectin sticks selectively to white blood cells by recognising something on their surface, they set out to find SLex.

Although myeloma is, like leukemias and lymphomas, a cancer involving white blood cells known as lymphocytes, myeloma cells don't traditionally express CD19 on their surface because they arise from the most mature type of lymphocytes — plasma cells.

An injection of SLex into the bloodstream should block the E-selectin on the surface of the blood vessels and so hide the chemical message that alerts the white blood cells.

Chemists in California have identified and synthesised a complex sugar molecule which lies on the surface of white blood cells, and through which the cells «recognise» those blood vessels that lie near injured tissue.

This relies on the ability of macrophages, types of white blood cell, to produce nitric oxide when they are exposed to cytokines.

However, the researchers observed that only 20 to 30 percent of HSCs took on this generalist role, contributing all of the most abundant types of white blood cells — called granulocytes, B cells and T cells.

Following up on clues — including the fact that PMS is 56 percent heritable — the NIH researchers studied the genetic control of gene expression in cultured white blood cell lines from women with PMDD and controls.

HIV infects white blood cells by sequentially attaching to two receptors on their surfaces.