Sentences with phrase «on young mice»

Researchers were particularly interested in studying the effects of the drug on young mice, which are still growing new bone and have much lower levels of sclerostin.

In their research on young mice, for instance, all the subjects died when they were infected with the Nodamura virus, but when Ding's researchers removed the suppressor protein called B2 from the virus, the infected mice began producing huge armies of the virus - attacking siRNAs and lived, unaffected by the otherwise lethal infection.

Not exact matches

Call me unambitious but I will always say the league cup is not worth the hassle, its I Micky mouse cup that should only be used to test young players I didn't want us to win it against Chelsea or Birmingham I fact I was partly cheering for the bromies we should be focusing on the league and maybe the F.A cup.

When B2M was administered to young mice, either via the circulatory system or directly into the brain, the mice performed poorly on tests of learning and memory compared to untreated mice, and neurogenesis was also suppressed in these mice.

«This well - designed set of experiments shows that chronic THC pretreatment appears to restore a significant level of diminished cognitive performance in older mice, while corroborating the opposite effect among young mice,» wrote Susan Weiss, director of the Division of Extramural Research at the National Institute on Drug Abuse, who was not involved in the study, in an e-mail.

As expected, young mice treated with THC performed slightly worse on behavioral tests of memory and learning.

The researchers conducted a series of micromanipulations on the eggs of mice between the ages of 6 and 12 weeks (young) and 60 - week - old mice (old).

Long after the treatments were applied, during a time point in mice that approximates young adulthood in humans, the investigators examined the impact of the simulated infections on the brain, comparing their results to those from mice that had received inactive injections.

The authors went on to study young mice with white - matter nerve damage similar to that seen in premature babies.

Using a surgical technique called parabiosis to join the circulatory system of a young mouse with that of an old one, the researchers studied the effects of young blood on elderly cells, and vice versa.

The GDF11 protein commonly found in the blood of young mice (the same protein that enhanced neurogenesis in aged mice) and placed in individual older mice was thought to have the same reversal effect on hypertrophy; however, more recent research suggests another molecule besides GDF11 may be at work.

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

«The effects of young blood on cognition have not been replicated by an independent group, and there has never been a test with a mouse model of Alzheimer's.»

A mouse study suggests marijuana may have the opposite effect on older people than it has on the young, boosting learning and memory instead of impairing it

Drawing on an odd experimental technique invented more than a century ago but rarely done now, researchers have found that a blood - borne protein makes old mouse hearts appear young and healthy again.

«It just reeks of snake oil,» said Michael Conboy, a cell and molecular biologist at the University of California, Berkeley, who's collaborated on studies sewing old and young mice together and transfusing blood between them.

When Wyss - Coray's team tried a simpler experiment than parabiosis — giving old mice injections of plasma from young mice — they saw similar effects on the hippocampal neurons.

For example, he learned that young pine snakes begin feeding on adult mammals — small ones, such as mice — within the first two months of life and they shed their skin multiple times within their first season.

Those headlines focused on the good news: Young blood rejuvenated old mice.

Although we did observe positive effects on some aging traits, such as memory impairments and reduced red blood cell counts, our studies showed that similar drug effects are also seen in young mice, indicating that rapamycin did not influence these measures by slowing aging, but rather via other, aging - independent, mechanisms.»

Prins investigated the effect of BPA on human cells by implanting human prostate stem cells taken from deceased young - adult men into mice.

To get around these safety concerns and to potentially maximize therapeutic effects on tumors, Alvey and colleagues took fresh, young macrophages from human donors as well as mouse donors and directly blocked their SIRPA.

As in the first study, a group of young mice carrying the human gene APOE4 showed cognitive impairment on the behavioral level — in other words, they showed signs of damage on the level of spatial memory.

The researchers harvested satellite cells from both healthy and injured muscle tissue of young mice and from healthy tissue of old mice; extracted these cells» DNA with the histone coatings intact; and used tagged antibodies targeting the different kinds of marks to find which spots on those histones were flagged with either «stop» or «go» signals.

Interrupting their development with antibiotics disturbs the metabolism of young mice and boosts their risk of obesity later on.

The effects of blood on ageing were first discovered in experiments that stitched young and old mice together so that they shared circulating blood.

In the young dystrophin - deficient mice, the respiratory control system was impaired on multiple levels.

Next, Abadir and colleagues compared the effects of different concentrations of losartan and valsartan on young diabetic and aged mice during the proliferation / remodeling phase of wound healing, which involves the regrowth of normal tissue.

«We were astonished that not only did this improve the mice's performance on the memory tests, but their performance was comparable to that of young mice,» said Dr. Pavlopoulos.

Using young and aged transgenic mice and human - derived induced pluripotent stem cells, she will examine the effect of Alzheimer's - related mutations on translation and protein expression.

What they discovered was that in young mice, the tiny protrusions that sometimes develop into longer spines on the receiving end of neurons grew at a rapid rate.

The scientists, who were looking at the impact of exercise on aging mice, found that a lifelong endurance regimen may help your body look and perform younger than its age.

We here studied, in intact young and aged adult mice, drinking - water (1μM) estradiol effects on both retention and organizational components of hippocampus - dependent memory, using a radial - maze task of everyday - like memory.

We did not test for aging - independent effects of rapamycin on hepatic microgranulomas, due to the relatively low prevalence of this pathology in young mice (Supplemental Table 8).

Few of the tested effects of rapamycin in our dataset were seen only in aged mice, not in young animals (RER, fat mass, γδ T cells, and CD44hi T cells); however, previous reports have shown aging - independent effects of mTOR inhibition on CD44 expression in T lymphocytes and fat mass (30, 31, 34).

(D) Effects of rapamycin on rbc count in young mice (control, n = 9; rapamycin, n = 8).

(G and H) Muscle fibers were automatically identified on H&E - stained sections of quadriceps femoris muscle of the 16 - month (G; young control, n = 786 muscle fibers from 5 mice; vehicle, n = 534 muscle fibers from 6 mice; rapamycin, n = 600 muscle fibers from 8 mice) and 25 - month (H; young control, n = 330 muscle fibers from 6 mice; vehicle, n = 741 muscle fibers from 4 mice; rapamycin, n = 1,371 muscle fibers from 5 mice) cohorts using image segmentation and analysis software.

(D) Effects of rapamycin on RER in young mice (control, n = 9; rapamycin, n = 8).

However, rapamycin also increased exploratory activity in young mice in our study, indicative of another aging - independent effect, rather than an effect on aging per se.

Remarkably, the older mice on the ketogenic diet had a better memory than the younger mice — months after they had gone off a ketogenic diet.

«The use of antibiotics in young children might lead to a higher risk of obesity, and two new studies, one on mice and one on humans, conclude that changes of the intestinal bacteria caused by antibiotics could be responsible.

While young mice (18 weeks, equivalent to young adults) lost only a few percent of body weight on the starvation low protein diets, elderly mice (2 years old) wasted away on low protein diets.

Other studies have noted that microbiota have an important influence on the development of cognitive processes in young mice (1).

Based on the children's picture book by author Julia Donaldson, this animated tale follows a creature called the Gruffalo and his young daughter, who wants to explore life outside of their clearing despite her father's warnings of a Big Bad Mouse that lurks in the forest.

On paper, the story of a young student's cat and mouse games with an elderly ex-Nazi in a quiet American suburb may have seemed like the stuff of awards, particularly with a towering Ian McKellen in the lead.

Based on a 1984 short film Burton made (which got him fired from his then job at the Mouse House), Frankenweenie tells the story of a young boy (voiced by Charlie Tahan) who loses his beloved dog after it runs into the street and is hit by a car.

Just like in nearly every other Pixar and Mouse House animated movie this Century, someone dies early on in «The Good Dinosaur» and Arlo must prove his worth as he battles enemies and the elements trying to make it back home to his family with the help of a new friend, a young cave boy.

This being a Mouse release, there are also a few extras for the young «uns on disc 1: sing - alongs to «Colors» and «Riverbend» (previously featured on a volume of Disney's old Sing - Along Songs VHS series) and the «Follow Your Heart» game.

When the economy rides and stumbles on $ 700 billion promises — and pocket money vanishes with a few clicks of a mouse — it becomes increasingly urgent to teach young people the basic survival skills of personal finance.

Square Enix's Disney mash - up is too easily misunderstood by those who may not have been young enough to appreciate the wonder of visiting a multitude of worlds from various classic House of Mouse movies, or appreciate the idiosyncrasies of travelling between worlds on what is basically a rocket - armed Lego spaceship.