I then came across the research of Dr. Alessio Fasano
on zonulin, a protein that is expressed in all autoimmune conditions and associated with increased intestinal permeability.
But then it also has some impact
on the Zonulin and the leaky gut.
Not exact matches
So, eventually they homed in
on a particular kind of protein called
zonulin, which is involved somehow in managing or manipulating the lining of, you know, the permeability of that intestinal wall.
Studies have shown the foods that contain gluten interfere with the functioning of a specific protein in your gut known as
zonulin, which wreaks havoc
on the intestines.
His discovery of the
zonulin / gluten affect
on intestinal permeability is not to be ignored.
He addresses the «Latest Research
on Leaky Gut» and shares about
zonulin.
The authors of the in vitro study state, «Based
on our results, we concluded that gliadin activates
zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules» (Drago et al., 2006, p. 408).
Read
on to learn about the utility of
zonulin testing and other measures of intestinal permeability in clinical practice.
Upon insult to the intestine,
zonulin is released from epithelial cells, where it can act locally
on receptors
on the apical (lumen - facing) membrane of nearby cells.
Gliadin,
zonulin and gut permeability: Effects
on celiac and non-celiac intestinal mucosa and intestinal cell lines.