Sentences with phrase «oncogene expressing cells»

It was even more surprising to observe that in absence of Sox9, pre-cancerous cells disappear over time, suggesting that we can eliminate oncogene expressing cells before cancer formation» comments Jean - Christophe Larsimont, the first author of this study.

Deletion of Sox9 prevents skin cancer formation demonstrating the essential role of Sox9 during tumorigenesis and leads to the progressive disappearance of the oncogene expressing cells.

The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.

Not exact matches

The group looked at an oncogene, AF1q discovered in Tse's lab, which is expressed in hematological cancer cells and is known to be related to multiple myeloma.

Proto - oncogenes consist of a group of genes / proteins that, when expressed, normally encourage cell survival, growth and proliferation, while tumor suppressors perform the opposite task, keeping cells from dividing out of control.

The group has also developed chemical inhibitors of ATR, which they showed were preferentially toxic for cells expressing oncogenes or lacking p53.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].