Early spaying may therefore, reduce occurrence of malignant lesions because the procedure removes the source of the hormones that cause some mammary cells to lose growth control, which puts these dividing cells at high risk for mutation and malignant transformation by environmental carcinogens.In fact, recent reports have identified activation of a specific
oncogene in a number of canine mammary tumors.
Assessment of predictive markers and patient stratification for treatment regimens for lung cancer: FGFR1 amplification is a potential driving
oncogene in lung squamous cell cancer (SCC), a subtype of non-small cell lung carcinoma (NSCLC).
«Discovering a new
oncogene in a tumor now allows one to ask the next big questions, what happens when you turn it off?
His lab discovered the first
oncogene in 1982 and the first tumor suppressor gene in 1986.
CARM1 is a known
oncogene in several cancer types, but prior to this study, there were no reports on its role in ovarian cancer.
«We expected Ezh2 to be
an oncogene in this aggressive tumor, but our gene - editing work revealed it to be a tumor suppressor,» said corresponding author Martine Roussel, Ph.D., a member of the Department of Tumor Cell Biology at St. Jude Children's Research Hospital.
The most commonly mutated
oncogene in NSCLC is the epidermal growth factor receptor (EGFR).
BRAF is a targetable
oncogene in the RAF / MEK / ERK pathway.
«I was immensely popular,» he says of the days when he found the first cancer - causing
oncogene in the Rous sarcoma virus.
V599EB - RAF is
an oncogene in melanocytes.
SGC0946 was found to selectively kills cells transformed with the MLL - AF9 fusion
oncogene in an in vitro model of leukemia.
Nevertheless, trying to develop new therapies based on what treatments will look like in the coming decade is a nearly impossible task, points out Michael Stratton, joint head of the Cancer Genome Project and professor of cancer genetics at the University of London's Institute of Cancer Research, who has been working on developing finely targeted cancer treatments since identifying the BRAF
oncogene in 2002.
A team of researchers, led by Keiko Kawauchi from the Mechanobiology Institute at the National University of Singapore, studied cells that had been transformed into cancer cells by Ras, the most common
oncogene in human cancer.
Collectively, we established SQLE as
an oncogene in NAFLD - HCC and propose that repurposing SQLE inhibitors may be a promising approach for the prevention and treatment of NAFLD - HCC.
The aim of this study is to elucidate metabolic adaptation to nutritional stress and the role of the involved
oncogenes in human colorectal cancer.
They discovered that the number of tumor suppressor genes or
oncogenes in a chromosome correlated with how often the whole chromosome or part of the chromosome was deleted or duplicated in cancers.
Other animal models either express
oncogenes in a tissue - specific manner or shut down the expression of tumor suppressor genes in the whole tissue.
He has over 250 publications in the areas of signaling by growth factor receptors and
oncogenes in breast tumor cells, development of targeted therapies and biomarkers of drug action and resistance, and investigator - initiated clinical trials in breast cancer.
Combining genetics, live - imaging, laser ablation and computer simulations, we aim to analyze whether distinct or similar mechanisms can account for the common role of tumor suppressors and proto -
oncogenes in cell - cell contact regulation.
Promoter hypermethylation of tissue specific tumor supressor genes and point mutation in K - ras, c - myc proto -
oncogenes in urinary (transitional cell) bladder carcinoma
Not exact matches
Sequencing
in one 18 - year - old patient found several
oncogenes, and her and her family will continue to work with Human Longevity to monitor the cells.
However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 —
in the smoke - exposed cells and a five - or - more-fold increase
in the signaling of the KRAS
oncogene that is known to be mutated
in smoking - related lung cancers.
We reasoned that if the hypothesis was correct, we might be able to find the src gene (the
oncogene of the Rous sarcoma virus)
in the DNA of normal cells.
In 1972 Dominique Stehelin, Harold E. Varmus and I set out to explore the «
oncogene hypothesis» proposed by Robert J. Huebner and George J. Todaro of the National Cancer Institute.
The team was successful
in getting the drug to piggyback on 123B9, an agent they devised to target an
oncogene called EphA2 (ephrin type - A receptor 2).
The findings, published
in Proceedings of the National Academy of Sciences (PNAS), define a mechanism
in which the
oncogenes turn on a protein called RSK2 that is required for cancer cells to move.
Seeking one mechanism to explain the induction of cancer by many different agents, Huebner and Todaro had suggested that retrovirus
oncogenes are a part of the genetic baggage of all cells, perhaps acquired through viral infection early
in evolution.
The results, still
in a preliminary stage, show that patients with a specific variant
in the RET gene - a proto -
oncogene or cancer driver gene; variant G2071A - could be more sensitive to this drug.
In addition to HPV
oncogene expression, the researchers noted other distinct differences between the HPV - inactive and active classes of cervical cancers.
Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound
oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes
in women with breast cancers.
«Physicians managing cervical cancer patients should test for HPV
oncogene expression
in these tumors and consider personalized treatment depending on HPV activity,» Banister said.
After a short postdoc at Cambridge sequencing cytomegalovirus, he landed a second postdoc
in a lab
in New York studying
oncogenes.
«Our study identified miR - 182 as a glioblastoma tumor suppressor that reduces the expression of several
oncogenes that promote cancer development,» said senior author of the study Alexander Stegh, an assistant professor
in the Ken and Ruth Davee department of neurology and of medicine at Northwestern University Feinberg School of Medicine.
They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target
oncogenes, regulate cell growth and differentiation, reduce tumor burden and prolong survival
in our mouse models.»
The group looked at an
oncogene, AF1q discovered
in Tse's lab, which is expressed
in hematological cancer cells and is known to be related to multiple myeloma.
However, on page 1391
in this issue, Yun et al. (5) show that high doses of vitamin C selectively kill colorectal cancer cells carrying activating mutations
in the
oncogenes KRAS or BRAF, which are often refractory to approved targeted therapies.
First, they are never
oncogenes; and second, the genes seem to be read normally whether or not a foreign sequence has jumped
in alongside them, which means that there is little danger of disrupting vital physiological processes.
In rapid - fire sequence he jumps from scientific minutiae to grand political comparisons (viruses, bacteria, oncogenes, even researchers who study these entities can be transformed into Goebbels or «good Germans»), and then he might toss in an entirely new idea before returning to his original topic — all within second
In rapid - fire sequence he jumps from scientific minutiae to grand political comparisons (viruses, bacteria,
oncogenes, even researchers who study these entities can be transformed into Goebbels or «good Germans»), and then he might toss
in an entirely new idea before returning to his original topic — all within second
in an entirely new idea before returning to his original topic — all within seconds.
Rather than bask
in the glory of having been first to isolate the
oncogene, Duesberg began to doubt that the enemy really was within.
Weinberg, who is also a professor of biology at MIT, says he has created cancer cells
in culture by adding
oncogenes — as, he stresses, have hundreds of others.
In 1984, while Duesberg was researching cellular and viral
oncogenes, he heard Margaret Heckler, who was Secretary of Health and Human Services, announce that his then friend Robert Gallo had discovered that HIV was the cause of the mysterious new plague known as AIDS.
Hehlmann is a strong supporter of his friend's cancer research, calling him the «father of
oncogenes» and a genius
in the field.
The three Ras genes found
in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other
oncogenes through an unexpected process.
«It wasn't known whether miR - 486 functioned as an
oncogene or a tumor - suppressor gene
in lung cancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics Program.
Blocking the function of the Ras
oncogenes is considered by many scientists to be the «holy grail» of cancer therapeutics because mutations
in these genes drive the growth of so many different types of cancers.
Sometimes
oncogenes manage to initiate tumor development
in the presence of p53, but, even then, the tumor suppressor doesn't give up and focuses its efforts instead on limiting the tumor's ability to invade and metastasize.
Among them: some genes believed to be tumor suppressors turned on or became more active, whereas certain disease - promoting ones, including
oncogenes (
in the so - called RAS family that are implicated
in both prostate and breast cancer), were down - regulated or switched off.
Tiny changes
in our genomes can enhance
oncogene expression and contribute to tumorigenesis [Also see Report by Mansour et al..]
The levels of miR - 34a were low
in pancreatic cancer mouse models, while the levels of the
oncogene were high.
Thus, the discovery that PTEN interacts with DAXX indicates it can regulate
oncogene expression
in cells by affecting H3.3 - chromatin binding.