Sentences with word «oncogenesis»

Professor, Molecular and Cellular Oncogenesis Program Scientific Director, Genomics Facility Scientific Director, Bioinformatics Facility Associate Director, Center for Systems and Computational Biology

Professor, Molecular & Cellular Oncogenesis Program Associate Director, Center for Systems and Computational Biology Scientific Director, Genomics Facility Scientific Director, Bioinformatics Facility

She completed her PhD investigating HPV - encoded proteins in oncogenesis with Dr Lawrence Banks at ICGEB Trieste, Italy, and postdoctoral research on the molecular biology of autophagy at Memorial Sloan Kettering Cancer Centre in New York.

The authors explain in the article that NSD1 mutation has recently been linked in the scientific literature to the blocking of cellular differentiation and the promotion of oncogenesis in this type of tumor.

«It is an honor very much deserved towards our understanding of alternate mechanisms of oncogenesis by virus infections,» Harper said in an e-mail.

Nucleophosmin - ALK mediates oncogenesis, at least in part, through phosphorylation / activation of PI3K and its downstream effector, the serine / threonine kinase AKT.

Consistent with this, more than 200 people have safely undergone adoptive transfer of genetically engineered lymphocytes with no reported cases of therapy - induced oncogenesis [55].

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression — Smruti Pushalkar — Cancer Discovery

Thus, the metabolic changes associated with oncogenesis may affect the epigenetic machinery, creating a feedback loop that synergistically promotes the progression of cancer.

[48] Mutations in GNAQ or GNA11 occur in the majority of uveal melanomas and drive oncogenesis via activation of the phospholipase C / protein kinase C (PKC), Rho / Rac, and Yes - associated protein pathways.

Alex Bishop, D.Phil., joined the Greehey Children's Cancer Research Institute in September of 2004 with major faculty responsibilities as a Principal Investigator in Molecular Oncogenesis.

Ziff had been working on the c - fos gene, which other researchers had shown was oncogenic, «but nobody knew how it worked or caused oncogenesis,» Kouzarides says.

CFSs now appear as preferential targets for oncogene - induced replication stress in precancerous lesions, which suggests that their instability promotes oncogenesis from early stages of the process.

The characterization of the genetic alterations observed in neuroblastoma led to the identification of major players of neuroblastoma oncogenesis that has considerably improved our understanding of the biology of this pediatric cancer.

Until now the mechanism by which the aberrant expression of glutamate receptor 1 in melanocytes leads to oncogenesis remains unknown.

Recent work from Fousteri Lab revealed a novel metabolic function of active transcription that is rapidly switched on globally in human cells to promote genetic accuracy, and reduce the mutation burden in genotoxins - exposed tissues, such as skin and lung, thus actively participating in lowering oncogenesis.

mTOR signaling in ALK + ALCL oncogenesis.

RalA and RalB proteins are key mediators of oncogenic Ras signaling in human oncogenesis.

In 2006, she became a Research Fellow at the Hormone Action and Oncogenesis group at the LRBGE and extended her work on GR biology and GR - target genes regulation in response to the ultradian secretion of glucocorticoids occurring naturally in mammalian systems.

Assistant Professor, Molecular and Cellular Oncogenesis Program Member, The Wistar Institute Melanoma Research Center

Caspar Wistar Professor in Computational and Systems Biology Director, Center for Systems and Computational Biology Co-Program Leader, Molecular and Cellular Oncogenesis Program Scientific Director, Proteomics and Metabolomics Facility

Recent studies have established that nucleophosmin - ALK mediates oncogenesis, at least in part, through phosphorylation / activation of the serine / threonine kinase AKT (4, 5).

In contrast, the safety record of hematopoietic stem cell gene therapy is less clear, with a significant frequency of gene - therapy induced oncogenesis or clonal outgrowth reported in several hematopoietic stem cell trials [56], [57].

«The work to understand the subtleties of how the EWS / FLI and GGAA - microsatellites interact to drive oncogenesis is foundational to our ability to develop new therapeutics against transcription factor - driven cancers,» says Stephen Lessnick, MD, PhD, director of the Center for Childhood Cancer and Blood Diseases at Nationwide Children's and senior author of the publication.

Since lentiviral vectors integrate into the genome, they could promote oncogenesis by altering local gene expression.

Myron Ignatius, Ph.D., joined Greehey Children's Cancer Research Institute as a Principal Investigator in the Fall of 2016 with major responsibilities in Molecular Oncogenesis and Cancer Genetics.

CFSs are loci that recurrently exhibit breaks on mitotic chromosomes following perturbation of DNA replication, and are now increasingly regarded as a driving force of oncogenesis.

Although its role in oncogenesis is poorly understood, expression of eIF4E has been reported in aggressive forms of non-Hodgkin's lymphoma and other cancers (37 — 39).

Adding to this storyline of APOBEC3A - mediated oncogenesis was the fact that expression of APOBEC3A was much higher in HPV - positive cancers.

Surprising experimental results indicating that having one extra chromosome actually impedes cancer rather than promotes it led a team of researchers to reconsider the relation between incorrect chromosome number and oncogenesis.

The Guardavaccaro group studies the functions of the ubiquitin system in normal cells and how deregulation of this system leads to oncogenesis.

In 1995, he took up his current positions as Professor and Chair of the Department of Immunology at the University of Tokyo, where he continues to study the regulation of immunity and oncogenesis by interferon - regulatory factors.

Louise Showe, Ph.D., professor in Wistar's Molecular and Cellular Oncogenesis Program, and scientific director of the Genomics and Bioinformatics facilities of the Institute, and Ramana Davuluri, Ph.D., former professor at Wistar, are the other co-inventors of the technology and will be serving as scientific consultants for ISOMA.

Caspar Wistar Professor in Computational and Systems Biology Professor and Program Co-leader, Molecular and Cellular Oncogenesis Program Director, The Wistar Institute Center for Systems and Computational Biology Scientific Director, Proteomics and Metabolomics Facility

[38 - 40] This discrepancy most likely reflects the fact that different factors lead to oncogenesis in the two types of melanoma.

Wistar scientists led by Maureen Murphy, Ph.D., professor and program leader of the Molecular and Cellular Oncogenesis Program, have found a novel mechanism through which mutant p53 enhances metastasis by controlling tumor metabolism.

In breast cancer, we found that obesity worsen breast cancer via S1P production (Hait NC et al, Oncogenesis 2015).

Caspar Wistar Professor in Melanoma Research Director, The Wistar Institute Melanoma Research Center Professor, Molecular and Cellular Oncogenesis Program

The mammalian IRF family contains nine members to date, IRF - 1 to IRF - 9, which have diverse roles in host defense, cell cycle regulation, apoptosis, oncogenesis, and immune cell development (5).

Caspar Wistar Professor in Computational and Systems Biology Director, Center for Systems & Computational Biology Co-Program Leader, Molecular & Cellular Oncogenesis Program Scientific Director, Proteomics and Metabolomics Facility

Professor, Molecular & Cellular Oncogenesis Program Strategic Adviser to the President

In this case, the viral protein managed to deregulate the cell cycle and induce oncogenesis.