«Microsatellite length and location appears to be essential for EWS / FLI to activate
the oncogenic gene targets,» says Dr. Lessnick.
Not exact matches
In addition, profiling has been exploited to identify non-coding RNAs that may represent downstream
targets of activated
oncogenic pathways or that are
targeting protein coding
genes involved in cancer.
We have hundreds of these
gene pairs in hand and are now developing drugs
targeting the synthetic lethal partner of major
oncogenic drivers.