Sentences with phrase «oncolytic virotherapy»

A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model

They found that PD - L1 immune checkpoint blockade significantly improved the therapeutic efficacy of stem cell based oncolytic virotherapy in melanoma brain metastasis.

Due to an increasing body of evidence which suggests that the host immune response may be critical to the efficacy of oncolytic virotherapy, Shah and his colleagues also developed an immunocompetent melanoma mouse model and explored treating with both stem cell loaded oHSV and immune checkpoint blockers such as the ones that target the PD - 1 / PD - L1 pathway.

Not exact matches

«Our data suggest that immunosuppression may not be the best strategy to help virotherapy do its job,» said Dr. Cripe, who was recently appointed as an associate editor of Molecular Therapy — Oncolytics.