Sentences with word «oncoprotein»

5) Saurabh K, Scherzer MT, Shah PP, Mims AS, Lockwood WW, Kraft AS, Beverly LJ (2014) The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.

E. Intensify research on the major drivers of childhood cancers Improve our understanding of fusion oncoproteins in pediatric cancer and use new preclinical models to develop inhibitors that target them.

It has also been reported that the ribosomal protein L11 interacts with oncoprotein HDM2 and inhibits the function of HDM2, thus leading to the stabilization and activation of p53 [20 - 22].

Why then Myc oncoprotein transformed cells succumb to ATP deprivation?

According to University of Helsinki scientist and Finnish Academy Research Fellow Juha Klefström, PhD, who led the study, «Myc oncoprotein not only boosts tumor cell proliferation but it also makes the cells vulnerable to cell suicide program, apoptosis.

The triggers for «non-stop» proliferation programs in cancer cells are the tumor - promoting oncoproteins, like protein called Myc.

In cells transformed by viral Src, or some other oncoproteins, the amount of phosphotyrosine shot up 10-fold compared to normal cells.

In ALK + ALCL, the most common chromosomal aberration involving the ALK locus is the t (2; 5)(p23; q35) resulting in expression of the chimeric nucleophosmin - ALK oncoprotein.

In parallel, as basic curiosity drove Lemmon and others to understand the mechanisms of these important signaling molecules, clinical researchers had begun to recognize that kinases with mutations often become oncoproteins.

Once taken up by antigen - presenting cells, which help focus the immune system on an invader, the vaccine releases a factor that heightens their attention specifically to the cancer - promoting protein E7, a so - called oncoprotein that not only enables the human papillomavirus to multiply, but potentially cervical cancer cells to do the same.

Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA and Xiong Y. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53 - dependent ribosomal - stress checkpoint pathway.

AKT is a well - known survival factor that phosphorylates and activates oncoprotein HDM2 (also known as murine double minute 2 (MDM2), HDM2 in humans), and in turn, HDM2 induces degradation of p53 [8, 9].

We showed that TCL1 oncoprotein associates with XBP - 1 and turns on vital ER proteins to support leukemic growth.

, Kraft AS, Beverly LJ (2014) The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.

The MYC oncoprotein is a central driver in the majority of human cancers.

Experiments in cell lines and animal models revealed that low SIRT6 levels in PDAC were correlated with increased expression of Lin28b, an oncoprotein normally expressed during fetal development.

Luckily, it seems that oncoproteins are not perfect programmers.

In pancreatic cancer cells, low doses of aspirin stopped the platelets from releasing growth factor and hampered the signaling of the oncoproteins that cause cancer to survive and spread.

They promote the growth of cancerous cells by releasing growth factors and increasing the response of certain proteins that regulate tumor cell development (oncoproteins).

«Our study reveals important differences and specificities in the mechanism of action of high - and low - dose aspirin in metastatic and nonmetastatic cancer cells with different tumor origins and suggests that the ability of aspirin to prevent platelet - induced c - MYC [an oncoprotein] expression might be selective for a nonmetastatic phenotype.»

He continued to use the detector for other projects, such as solving (in collaboration with SBGrid member Emil Pai, biochemistry professor at the University of Toronto) the RAS p21 protein, an oncoprotein in human cancer.

«And they realized that oncoproteins were doing a lot inside cells, more than just phosphorylating themselves,» he says.

While still in Heidelberg, Pai had participated in applying a technique called time - resolved crystallography to p21, an oncoprotein, making it possible to watch the structure change over time, as in a video.

PI3K - AKT signaling has been reported to promote the activation of the oncoprotein HDM2 and to downregulate the p53 tumor suppressor [28], and therefore AKT is defined as a survival factor.

These observations demonstrate that with a pregnancy preexisting premalignant mammary cells overcome both the apoptotic response to an oncoprotein and the robust cell death at involution, which normally clears the large mass of cells gained during pregnancy / lactation.