Sentences with phrase «one's clinical relevance»

Given the key role of emotion regulation in supporting mental health and other adaptive outcomes, such understanding may have important clinical relevance as well.

The selenium - thyroid connection has significant clinical relevance, because blood, but not tissue, levels of thyroid hormones rise in selenium deficiency.

I'm particularly proud that we started from the basic research interest and it's now developed into clinical relevance.

Therefore, studying their early representations appears to be of particular clinical relevance.

«In the past year, there have been several successful large genome - wide association studies of reproductive behaviors; in that context, I think this study is particularly important because of the immediate clinical relevance of gestational timing,» says David Hinds, PhD, 23andMe Principal Scientist and Statistical Geneticist, who helped to co-author the paper.

Supporting focused research based on priorities of immediate clinical relevance to Australians, and in key areas such as Indigenous health, rural and remote health, and application of genomics to personalised medicine

The Foundation has actively participated to develop a large number of National / Ethnic Genetic databases and related software that record the incidence of genetic diseases and the corresponding genome variation spectrum, with clinical relevance in various populations and ethnic groups worldwide.

«We believe that this finding has important clinical relevance because we can potentially prevent or decelerate the progression of colorectal cancer in humans, especially in those who have mutations in the AIM2 gene, by simply giving them «good» microbiota.»

«This has potential huge clinical relevance,» de Lecea said.

Researchers now need to evaluate MIF levels in human diabetics to establish clinical relevance, he adds.

Given the broad clinical relevance of dysfunctional social cognition in diverse psychiatric disorders, a better understanding of the neurobiological foundations of social cognition is urgently required for the development of novel and targeted therapies (6).

This kinase receptor has important clinical relevance, as EGFR deregulated signalling is strongly associated with cancer.

While the administration of singular or small groups of select beneficial microbes may not have a major impact on stable phyla, probiotic intervention studies (as discussed previously) have taught us that species - level application of microbes are not without clinical relevance.

CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that RCT was a viable treatment option to salvage endodontically diseased canine teeth in cats.

The model could therefore be used to identify molecular mechanisms with the most clinical relevance, or to help us understand the pathogenesis of different monogenic forms of NS.

Another measure of clinical relevance which has emerged recently is the increased hypersensitivity to pain stimuli caused by sleep restriction in rats.

This, claims Dr Cederroth, not only has considerable clinical relevance but is also important from a public health perspective:

The temporomandibular joint, or TMJ, is also of growing clinical relevance, Vunjak - Novakovic adds.

Although you don't need to be at a medical school to have a great technology transfer office, tenOever notes, «That, to me, is a very good push toward clinical relevance.»

Pickles and Liesman then used their reengineered PIV expressing RSV NS2 in animal models to provide more clinical relevance for their findings.

This interval straddles values from no effect to clear clinical relevance.

The hematopoietic system provides a good model system to inform interpretation of association studies owing to simple phenotypes at the cellular level; nearly unlimited access to suitable tissue with good ability for in vitro manipulation; suitable model organisms; widespread clinical relevance.

The authors highlight that these sex differences have to be considered before starting metabolically active drugs, because higher plasma glucose levels were also associated with increased glucose kinetics, in diabetic patients, and this might have clinical relevance especially during ischemia.

To extend novel observations generated from epidemiology studies to translational studies with direct clinical relevance.

Wiersinga WM. Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease.

CONCLUSIONS AND CLINICAL RELEVANCE Clinicians should note the 25 % mortality rate of the dogs with parvoviral enteritis that received outpatient care in this study setting when discussing treatment options with owners of affected dogs who are financially unable to pursue hospitalization.

When laboratory testing is performed, detected changes are often of little clinical relevance and do not prompt major changes to be made to the anaesthetic technique.»

These studies are important because of their evident clinical relevance, but also because studies that involve interventions provide greater information on causal processes between sensitivity and development, than do correlational designs.

Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance

The team also conducted two clinical translation studies to test whether pharmacologically blocking miR -17-92 might have clinical relevance in the lupus - like condition and the scleroderma cGVHD model.

Second, beige fat may be more interesting from an anti-diabetic, metabolic standpoint — a finding with significant clinical relevance — than from a body temperature, warming standpoint,» explained Dr. Scherer, who holds the Gifford O. Touchstone, Jr. and Randolph G. Touchstone Distinguished Chair in Diabetes Research.

Again, modern imaging methods are enabling this information to be translated to the developing human brain (27), and indeed, imaging with neuropsychology is an area where rapid progress is being made and needs to be made to translate the growing basic neuroscience knowledge of mechanisms into clinical relevance and application.

Antibodies generated in humans to DENV are of particular clinical relevance, because they have the potential during a subsequent infection to protect from or increase the risk of developing DHF.

Inventors at MUSC have identified a unique human CD4 + T cell population that expresses high levels of surface CD26, termed CD26high T cells, which mediate durable antitumor immunity in vivo, and have immediate clinical relevance for designing new vaccines and cellular therapies.

«Focusing on stopping the changes that occur in astrocytes and microglia has clinical relevance because most people don't know they're getting ALS, says Dr. Kaspar, who also is an associate professor of pediatrics and neurosciences at The Ohio State University College of Medicine.

«This has potential huge clinical relevance,» senior author Luis de Lecea, professor of psychiatry and behavioral sciences, said in a university news release.

These findings have broad clinical relevance, notes lead author Stephanie Eisenbarth, M.D., Ph.D., assistant professor of laboratory medicine, immunobiology and medicine at Yale.

CONCLUSIONS AND CLINICAL RELEVANCE Results should be cautiously interpreted because of potential respondent and recall bias and lack of review of medical records.

Performed pro-bono work investigating small cap pharmaceutical companies, ensuring scientific and clinical relevance for target drugs, revenue forecasting, market research for drugs with similar target molecule

Understanding the influence of parent ADHD has important clinical relevance; if having a parent with ADHD indexes a more severe child clinical presentation, regardless of whether these links are inherited and / or environmental, then it may be important to ask about parental history during clinical assessment.

Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance.

Examples include a series of studies to document persistent microchimerism of donor cells in transfusion recipients, with particular focus on mechanisms and clinical relevance of donor stem cell microchimerism in transfused trauma patients, and the immunological mechanisms and prevention of transfusion - related acute lung injury (TRALI) and alloimmunization.

The implication of these findings for guiding policy is unclear; future research should investigate the «clinical relevance» of these differences in nutritional quality.