That suggests that the cells have gone beyond pluripotency and taken on some characteristics of totipotent cells, which are even more developmentally primitive and can produce not
only embryonic tissues, but also the supporting tissues such as placenta.
Not exact matches
The results help fill in the scientific puzzle kicked off by Dolly's cloning, which proved that mammalian egg cells were capable of dissolving the genetic roadblocks that limit the potential of most adult cells to give rise to
only a single type of
tissue — that of the organ from which they hail — whereas
embryonic stem cells have the potential to become virtually any kind of body
tissue.
In contrast to
embryonic stem cells, when adult stem cells divide, their offspring are
only able to develop at the same site and in certain
tissue types.
Later he found that TCF - 1 is part of the larger Wnt family of signaling molecules that's important not
only for immune responses, but also for
embryonic development and
tissue repair.
They propose that normal
tissue becomes primed for cancer when oncogenes are activated and tumor suppressor genes are silenced or lost, but that cancer develops
only when a cell in the
tissue reverts to a more primitive,
embryonic state and starts dividing.
The ability of a fertilized egg to generate both
embryonic and extra-
embryonic tissues is referred to as «totipotency,» an ultimate stem cell state seen
only during the earliest stages of
embryonic development.
Vermulst's study looked
only at
tissues from the heart, brain, and
embryonic fibroblasts.
While much recent research has not been published in this area, there is actually a long history of studies that show: (1) there is a significant number of antigens shared between tumors and
embryonic tissues (called «oncofetal antigens») and, consequently, antibodies made against tumors can also recognize
embryonic tissues, and vice versa; (2) pregnancy confers some immunity against cancer (accompanied by antibody production against oncofetal antigens), not
only against its occurrence but also against its growth; (3) similar to pregnancy, an immune response against cancer can be generated by vaccinating animals with
embryonic tissues.
This approach to derive patient - specific
Embryonic Stem cell - like cells (iPS cells) is going to open up research into the genetic causes of disease and the search for therapies not
only for such diseases, but also for repairing
tissues damaged in other ways.
Previous studies, however, were not able to develop
tissue replacements that have hair follicles because it is
only present in
embryonic organogenesis.
Adult stem cells were once believed to be more limited than
embryonic stem cells,
only giving rise to the same type of
tissue from which they originated.