At least six different estrogens have been identified, but
only estrone, estradiol (E2), and estriol are circulate in significant quantities in the blood.
Not exact matches
Estradiol falls generally to about 15 percent of premenopausal levels, and
estrone falls
only 40 to 50 percent of premenopausal levels.
Serum hormone tests typically include measurements
only of total estradiol (E2), although total
estrone (E1, the most potent and potentially oncogenic estrogen) may be available.
(2) The «Estrogen Quotient» (EQ): also available
only via the 24 - hour urine test since it requires assessment of the levels of free
estrone, free estradiol and free estriol.
To be able to safely and effectively prescribe hormone replacement therapy (BHRT or HRT) will necessitate knowing not
only how much
estrone, estradiol and estriol are in circulation, but how much is active (free plus conjugated [potentially active]-RRB-, and into what forms each estrogen is being metabolized: Is she predominantly producing protective or carcinogenic estrogen metabolites?
It contains 48 %
estrone and
only a small amount of progesterone, which is insufficient to have an opposing effect.
Estradiol is more prevalent with women of childbearing age, estriol becomes dominant during pregnancy, and
estrone is the
only estrogen a women's body makes after menopause.
Here is a fascinating data point: flaxseed does not
only suppress estradiol production but it also nudges estradiol metabolism into a positive direction by generating a higher ratio of the protective metabolite 2 - hydroxy -
estrone versus the more harmful 16 - hydroxy -
estrone.
Estradiol and
estrone are found in both men and women, with estriol
only being associated with pregnancy.