Sentences with phrase «only in aged mice»

Few of the tested effects of rapamycin in our dataset were seen only in aged mice, not in young animals (RER, fat mass, γδ T cells, and CD44hi T cells); however, previous reports have shown aging - independent effects of mTOR inhibition on CD44 expression in T lymphocytes and fat mass (30, 31, 34).

Not exact matches

«Aging - induced inflammatory activation of microglia could only be prevented when mice were fed a low - fat diet in combination with limited caloric intake,» says Eggen.

Conversely, Tg - hIAPP mice inoculated with WT pancreas homogenate (hereafter referred to as the Tg / WT group) only began to show small IAPP aggregates at around 20 wk of age (Fig. 3, A and B), in a manner similar to untreated Tg mice.

Although of course there are a number of caveats since mice can be cured from cancer at higher rates, they don't suffer from some of our diseases, they are sensitive to being handled (if grabbing them can shorten their lifespan through stress, the mouse version of standard human medical care may do the same), so I guess that increases in maximum lifespan are indeed the only reliable indicator that an intervention is impacting age - related mortality.

In an operant test R6 / 2 transgenic mice (240 - CAG repeats, B6 congenic background) were less able to acquire lever pressing than control animals at an age where motor function is only mildly affected (from 9 weeks), with this deficit being both more pronounced and detected earlier (from 5 weeks) where reinforcement was not solely contingent on responding.

Interestingly, we detected upregulation of p16 and p15 in Polycomb - null skin epithelial stem cells in young mice where it is normally detected only in aged animals.

In addition, 110 CAG mice exhibited tremors at rest at early ages, but the 240 CAG mice only showed tremors at later ages and only after manipulation.

[19] In the current study, [15] PDGF - AS mice exhibited an increased number and intensity of areas staining for reactive microglia (using Iba1) and astroglia (using GFAP), but vaccination with AFF 1 prevented nearly all of this disease - associated excess, with treated animals exhibiting only the burden of reactive glia present in similar - aged WT micIn the current study, [15] PDGF - AS mice exhibited an increased number and intensity of areas staining for reactive microglia (using Iba1) and astroglia (using GFAP), but vaccination with AFF 1 prevented nearly all of this disease - associated excess, with treated animals exhibiting only the burden of reactive glia present in similar - aged WT micin similar - aged WT mice.

In the climbing task, 90 % of the 110 CAG mice stopped climbing by 6 weeks of age in contrast to the 240 CAG repeat cohort in which only 55 % had stopped climbing by 8 weeks of agIn the climbing task, 90 % of the 110 CAG mice stopped climbing by 6 weeks of age in contrast to the 240 CAG repeat cohort in which only 55 % had stopped climbing by 8 weeks of agin contrast to the 240 CAG repeat cohort in which only 55 % had stopped climbing by 8 weeks of agin which only 55 % had stopped climbing by 8 weeks of age.

We demonstrated that this device could reduce the KLRG1 - positive CD8 cell count in aged mouse blood by a factor of 7.3 relative to the total CD8 cell compartment, reaching a level typically seen only in very young animals.

Although we can not rule out that exercise might also increase hippocampal progranulin in 2 - to 3 - month - old Grn + / − mice, there is no data that an increase of this magnitude (only 10 — 15 %) restricted to hippocampus would be sufficient to produce functional improvement, and the fact that the effect is not sustained even until ∼ 4 months of age makes it highly unlikely to yield any sustained benefit after onset of functional changes between 6 and 12 months.

The findings thus provide preliminary evidence for an interaction between age and exercise in modulating progranulin expression, with effects of exercise only in very young mice.

The mice used in all these the studies were treated with memantine from a very young age, and we don't know what would happen if the mice received it only after they got sick - which is how most human patients are treated.

A reanalysis of genes tied to life span in mice reveals only a select few affect aging.

In one Japanese study, for instance, researchers were only able to change the baseline stress characteristics of germ - free mice until nine weeks of age.