Sentences with phrase «only on gene expression»

Garcia - Ojalvo expressed surprise that a network based only on gene expression data could predict, with relative accuracy, the effect of multiple genetic interactions.

Not exact matches

Neuroscientists have over the past decade uncovered evidence, both in rodent and human studies, that parental caregiving, especially in moments of stress, affects children's development not only on the level of hormones and brain chemicals, but even more deeply, on the level of gene expression.

Only a decade later was it confirmed to bind to DNA and turn on the expression of other genes aimed at healing cell damage.

«As a result of the previous study, we reported that SUMO is probably important for controlling expression of active genes because we found it on every gene we looked at, but only when they were turned on,» notes Rosonina.

Crucially, the team also showed that a serotonergic neuron's gene expression and function depend not only on its location in the adult brain stem, but also on its cellular ancestor in the developing brain.

Because genes on the Y chromosome often vary slightly in sequence — and even function — from the corresponding genes on the X, males could have slightly different patterns of gene expression throughout the body compared with females, due to not only their hormone levels, but also their entire Y chromosome.

Not only were levels of metabolic compounds different, but the expression of certain genes involved in metabolism was turned up, and the epigenome of the cells — molecular markers on DNA that change gene expression on a broader scale — was altered.

On average we found only 54 genes per tissue (0.2 %), which showed significant correlation of gene expression with PMI (FDR < 1 %)(Fig. 3a, Supplementary Table 6), compared to 6919 genes per tissue (39.3 %), if using the same model without covariates.

«Methods currently used for measuring gene expression generally rely on something called «relative normalisation», which means that gene expression levels in a sample can only be estimated relative to other genes in the same sample.

But by placing the gene under the control of a «promoter» — an on - off switch for gene expression — from a gene (SM22a) that is expressed only in smooth muscle cells, Dr. Parmacek's team found that no matter which types of cells were infected, the gene was only «turned on» in smooth muscle cells.

Based on this classification of evolutionary age of each gene, induced genes are much younger than either non-regulated or repressed genes: excluding those genes without significant expression, induced genes are only 37.9 % Metazoan compared to 64.5 % Metazoan for non-regulated genes and 55.9 % Metazoan for repressed genes (Figure 4A).

It matters, as far as gene expression is concerned, only if it occurs in a «promoter» region, a sequence of DNA needed to turn a gene on or off.

He and others had developed that technique, known as conditional expression, to turn a gene or mutation on or off only in a desired tissue or at specific life stages.