The peripheral sink Aβ hypothesis indicates that the peripheral clearance of Aβ and its regulation by dietary phytosterols is of substantial interest since it may delay hypercholesterolemia and the early onset of amyloid plaque development.
In persons with the disease, the formation ofamyloidplaque aggregates, a process known to cause the onsetof Alzheimer's disease, prevents the Crtc1 protein from functioning correctly.