TrialNet is a NIH funded consortium
of Centers
conducting a variety
of intervention trials in recent ‐
onset type 1 diabetes and in subjects at risk
of the disease, as well as further defining the natural history
of the disease and its pathophysiology (link).
Rather fewer meet the diagnostic criteria for research, which for the oppositional defiant
type of conduct disorder seen in younger children require at least four specific behaviours to be present.7 The early
onset pattern — typically beginning at the age
of 2 or 3 years — is associated with comorbid psychopathology such as hyperactivity and emotional problems, language disorders, neuropsychological deficits such as poor attention and lower IQ, high heritability, 8 and lifelong antisocial behaviour.9 In contrast, teenage
onset antisocial behaviour is not associated with other disorders or neuropsychological deficits, is more environmentally determined than inherited, and tends not to persist into adulthood.9