Research activites of the faculty focus on equine
oocyte activation and immunocontraception.
Oocyte activation ability correlates with head flatness and presence of perinuclear theca substance in human and mouse sperm.
Appearance of
an oocyte activation - related substance during spermatogenesis in mice and humans.
Not exact matches
Gene
activation was also reversed in the
oocytes of TGF - β mutants.
Murphy found that the normal pattern of gene
activation seen in aging wild - type C. elegans was reversed in the body cells and
oocytes of IGF - 1 mutants.
Alison Murdoch of the Newcastle center noted that crucial knowledge is still lacking on what constitutes a «good» egg, on «what is the appropriate
activation signal» for the
oocyte, and on how long nuclear reprogramming takes.
The paper «Non-canonical function of SAC proteins after APC
activation reduces aneuploidy in mouse
oocytes» is published in the journal Nature Communications and was funded by the Australian Research Council.
BRCA1 is required for meiotic spindle assembly and spindle assembly checkpoint
activation in mouse
oocytes.
A possible explanation for this finding is that residual mRNA expression from
oocytes was still present in morula stage parthenotes and / or chemical
activation induced the aberrant expression of certain genes in parthenotes.