Sentences with phrase «open chromatin regions»

Additionally, we found that DNA loss events tended to be smaller than DNA gain events suggesting that they were able to accumulate in gene - rich open chromatin regions due to their reduced capacity to interrupt gene regulatory architecture.

These open chromatin regions are known to be key locations in the genome that control which genes are expressed and which aren't.

Not exact matches

But what they found is that the host chooses which chromatin regions are opened to make genes available for use in each region of the intestine.

The application of next - gen sequencing to RNA libraries (RNA - Seq), chromatin immunoprecipitates (CHiP - Seq), bisulfite - treated DNA, and regions of open chromatin (DNAse - Seq) makes it possible to interrogate many aspects of the genome in high - throughput fashion.

This is consistent with a model in which DNA gain and loss results in turnover or «churning» in regulatory element dense regions of open chromatin, where interruption of regulatory elements is selected against.

First, hot spots for DNA gains and losses occur in different compartments; loss hot spots in open chromatin / regulatory regions and gain hot spots in heterochromatin.

The DNase I restriction enzyme cleaves regions of open chromatin, and it preferentially does so at places where, nearby, there are non-histone proteins bound to DNA.

Regulatory elements tend to occur in regions of open chromatin (euchromatin), where they are accessible to transcription factors and other proteins.