Sentences with phrase «open chromatin structure»

At sites of UV damage, E2F1 recruits the histone acetyltransferase GCN5, which acetylates histone H3K9 in order to open chromatin structure and increase accessibility to the damaged site by the DNA repair machinery.

In the early embryo, TH2A and TH2B bind to DNA and induce an open chromatin structure in the paternal genome, thereby contributing to its activation after fertilization.

Not exact matches

Depending on the tissue type and what jobs that tissue is doing, distinct portions of DNA are unspooled to become available for activity through a structure called open chromatin, said Gregory Crawford, an associate professor of pediatrics and expert on gene expression.

Neocentromeres have also been shown to harbor expressed genes [13], and the rice finding shows that the chromatin structure of both plant and mammalian CenH3 - binding domains is open and accessible to the transcriptional machinery.

Trowbridge hypothesized that analyzing open chromatin in bulk tumor cells could provide a possible improved method to identify cancer cell of origin because of the cell - type specificity of chromatin structure.