Sentences with phrase «open reading frame»

Translation then switches from the defective message to a short open reading frame on tmRNA that tags the defective nascent peptide chain for degradation.

Additionally, P - eIF2α dependent translation of mRNAs regulated by upstream open reading frames (uORFs) contributes to the molecular signature of stemness.

The manuscript entitled «The oncogenic protein kinase MELK is essential for mitotic progression in basal - like breast cancer cells» begins with a functional overexpression screen utilizing a library of open reading frames encoding human kinases.

Boxes above the central black line represent open reading frames (ORFs) that are encoded on the forward strand, while boxes underneath the black line represent reverse - strand encoded ORFs.

Although the region immediately around the CentO tracts for both centromeres 4 and 8 consists entirely of repetitive elements, the 750 kb CenH3 - binding domain of rice centromere 8 included 14 putative non-retroelement open reading frames (ORFs), including 4 that were shown to be expressed by reverse - transcriptase - coupled PCR [6].

It is known that one of the pathways involved in cutaneous cancer is mediated through CDKN2A which is a gene associated with melanoma dysregulation through its pro-oncogenic products p16INK4a (Cyclin - Dependent Kinase Inhibitor P16) and p14ARF (P14 alternate open reading frame)[28].

The sequence of this region is nearing completion by the BDGP and an attempt is being made to correlate open reading frames and transcription units with genetic loci (see Figure 4).

To test for Plasmodium falciparum DNA, PCR primers were designed that specifically amplify small subtelomeric variable open reading frame (STEVOR), apical membrane antigen 1 (AMA1), and merozoite surface protein 1 (MSP1) gene fragments with sizes of 100 to 250 base pairs (bp).

The flavivirus genome, approximately 10.5 kb in size, encodes three structural proteins [capsid (C), membrane (PrM and M) and envelope (E)-RSB- and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) in one open reading frame with subsequent cleavage [9].

The predicted open reading frames (ORFs) for most of these transcripts are truncated, due to a premature stop codon.

Pools of retroviral vectors encoding 354 human kinases and kinase - related proteins (37 pools in total, each consisting of 10 — 12 unique open reading frames) were transduced into HMED - DD - NeuT cells.

In this study, we report the identification of MELK as a novel oncogenic kinase from an in vivo tumorigenesis screen using a kinome - wide open reading frames (ORFs) library.

Open boxes indicate untranslated regions and colored boxes indicate open reading frames.

The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide.

His miRNA switches consist of synthetic mRNA sequences that include a recognition sequence for miRNA and an open reading frame (ORF) that codes a desired gene, such as a regulatory protein that emits fluorescence or promotes cell death.

Patients with mutations in the chromosome 9 open reading frame 72 (C9ORF72) gene have all or some symptoms associated with both disorders.

The deduced genomic structure of TMAdV was also similar to that of other mastadenoviruses and consists of 34 open reading frames (Fig. 2C).

Frequently insertions / deletions alter the open reading frame (ORF) of the target gene, disrupting the gene function downstream of the DSB.

Each allele eliminated the pathogenic p.K1872X mutation and removed 59 or 22 amino acids from the predicted encoded protein, while restoring the open reading frame to encode the critical C terminal region of BRCA2 (Fig. 1C, labeled D1 and D2, Supplementary Tables S1 and S2).

Permission of the principal investigator should be obtained before publishing solely bioinformatic analyses (e.g. metabolic reconstruction, synteny) of unpublished sequence / open reading frames / genes on a chromosome - or genome - wide scale.

The start and stop codons tell the ribosome where to start or stop translating and this way they define an open reading frame.

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