Sentences with phrase «opens chromatin so»
TCF - 1 ultimately opens chromatin so that DNA can be read to make proteins, and it also keeps chromatin open so that subsequent factors can access DNA to make protein that guide a maturing T cell to its final identity.
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Certain chemical groups on histones allow DNA to open up, and others to tighten the chromatin, and so creating availability to be read and expressed as proteins.
The DNase I restriction enzyme cleaves regions of open chromatin, and it preferentially does so at places where, nearby, there are non-histone proteins bound to DNA.