Sentences with phrase «opioid agonist»

Buprenorphine is a partial mu opioid agonist.

Breastfeeding should be encouraged in women who are stable on their opioid agonist, who are not using illicit drugs, and who have no other contraindications, such as HIV infection (73, 74).

And in a paper out this week in Cell, a veteran opioid researcher and her colleagues unveil new biased opioid agonists that could surpass oliceridine, though they haven't been tested in people yet.

A method for conducting functional MRI studies in alert nonhuman primates: initial results with opioid agonists in male cynomolgus monkeys.

Not exact matches

Fentanyl is actually a better agonist (bind more efficiently) to the opioid receptors in the CNS and has less nonspecific binding so it actually causes less general side effects.

Indeed, our bodies use endo - cannabinoids in much the same way as they use opioids in the central nervous system: as synapse agonists and antagonists.

«Countries using these measures should instead increase the availability of proven opioid - agonist therapies, such as methadone, and ensure there is adequate access to voluntary treatment programs in community settings and facilitate people with opioid addiction to seek treatment.»

Dr. Bohn's team has identified several molecules considered to be «biased agonists» because they act at the opioid receptor to stimulate pain relief, but cause less stimulation of the pathway that leads to respiratory suppression.

While biased agonists may be able to be used more safely at higher doses than other opioids, it remains to be seen how other side effect profiles will be affected.

Sex differences in sensitivity to the depressive - like effects of the kappa opioid receptor agonist U-50488 in rats.

She envisions that chronic pain patients may benefit from the combined pain relief of a CB2 agonist and a low - dose opioid.

Characterization of Neuroprotective Effects of Biphalin, an Opioid Receptor Agonist, in a Model of Focal Brain Ischemia.

Wang D, Sun X, Sadee W. Different effects of antagonists on mu -, delta -, and kappa - opioid receptors with and without agonist pretreatment.

When an opioid binds to a receptor, it may cause increased receptor activity with a maximum effect (agonist), increased receptor activity that plateaus at an effect lower than maximum (partial agonist), or decreased receptor activity (antagonist).6

Common pharmaceuticals range from opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) to α2 - agonists, gabapentin, amantadine, ketamine, and local anesthetics.

Recommended combinations for such injections include α2 - adrenoceptor agonists, opioids, and dissociative drugs.

Agonists of the µ - opioid receptor also have antidepressant effects (Berrocoso et al., 2009).