«Pain sensitivity is a major issue for users of
opioid drugs because the more you take, the more the drug can increase your sensitivity to pain, so you may never quite get the level of relief you need.
Not exact matches
As Andrew explains, it is the most insidious development yet in the
opioid crisis: «It —
because of its potency — is killing so many more people so much more rapidly than the prescription
drugs or even the heroin did.»
The U.S. Food and
Drug Administration has strengthened the label warning to state that breastfeeding is not recommended while using medicines containing codeine or tramadol
because of the potential for serious adverse effects in the infant due to
opioid overdose (76).
Narcotics dealers selling chemically altered mixtures that contain the powerful synthetic
opioid fentanyl can face weaker punishments
because of a loophole in state law that exempts certain
drug mixes from being illegal controlled substances.
The maker of Suboxone, a blockbuster
drug that helps people control their
opioid addiction, engaged in anti-competitive business practices, coercing patients to use an oral strip
because the tablets were set to face generic competition, according to a federal lawsuit filed by New York Attorney General Eric Schneiderman and 35 other Attorneys General.
Only a year ago, he said he opposed legalizing recreational marijuana use
because it is a «gateway
drug» to stronger
drugs like
opioids and he took several years to embrace efforts to legalize marijuana for medical purposes.
But
because of the high potency of
opioid drugs sold and used in Erie County, emergency personnel often find they need to use multiple doses to revive overdose victims.
Some people who have primarily abused
opioid pain medication have turned to gabapentin after crackdowns made it more difficult to obtain
opioid prescriptions or purchase the
drug on the street
because of its expense.
While this approach works well in most cases, it is necessary to view regulatory oversight of
opioid medications differently from that of other
drugs,
because these medications can have a number of consequences not only at the individual level but also at the household and societal levels.
The «other victims» of the
opioid epidemic are pain patients who need the
drugs but can not now get them
because of fears related to their use
The growing availability of prescription
opioids has increased risks for people undergoing treatment for pain and created an environment and marketplace of diversion, where people who are not seeking these medications for medical reasons abuse and sell the
drugs because they can produce a high.
Because GABA B is in a different class from
opioid receptors, potential side effects in such a
drug would be limited.
A team at Massachusetts General Hospital scrutinized the
opioid system, the reward pathway hijacked by
drugs such as heroin,
because the researchers had earlier found that beta - endorphin and the skin pigment melanin originate from the same protein.
This is
because the
drug binds so tightly to the brain's
opioid receptors that naloxone, at currently common doses, is unable to dislodge that bond and reverse its sedating effects to get patients breathing again, says Michael Lynch, the medical director of the Pittsburgh Poison Center.
And an overdose of marijuana is never fatal
because the
drug doesn't slow heart rate and breathing as
opioids do.
Because high doses of
opioids have the potential to cause respiratory arrest or other dangerous side effects, doctors may hesitate to give patients as much of the
drugs as they need to relieve their pain, says David Soergel, chief medical officer at Trevena.
Sigma receptors were discovered in the 1970s
because of their response to analogs of
drugs that activate
opioid receptors.
A doctor in Oklahoma has been charged with five counts of second - degree murder after her patients died
because of
opioid drug overdose.
Of those, 22 cases had not been reported to statewide
opioid surveillance
because the involvement of
drugs hadn't been listed on the death certificate.
Called the «overdose
drug»
because it counteracts the potentially lethal effects of heroin, oxycodone, and other abused narcotics, this lifesaving medicine is making headlines thanks to the
opioid addiction epidemic.
A couple other things to consider are that
because LDN blocks the
opioid receptors, some pain narcotic
drugs like Percocet or morphine or tramadol, LDN can decrease their effectiveness so that typically they shouldn't be taken together.
This is currently happening in Toronto, where Harm Reduction Workers set up an illegal pop - up overdose prevention site in Moss Park
because they believed the
opioid crisis is at a point where
drug users in the city can not wait months for a legal supervised injection site...
Without that money, the U.S. can't stem the tide of the
opioid epidemic, says Chrissie Juliano, director of the Big Cities Health Coalition,
because it is used for programs designed to prevent
opioid addiction, such as prescription
drug monitoring.