Sentences with phrase «optic nerve axon»

Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss.

Not exact matches

And in transgenic pups whose optic nerves were surgically severed 4 days after birth, retinal axons grew around the gap, finding their way to the proper target areas in the brain.

«We looked at the optic nerve and saw normal myelination,» Mukherjee said, referring to the fatty white sheathing wrapped around axons, the nerve fibers that allow information transmission over distances to proceed efficiently and rapidly.

A healthy optic nerve has axons transmitting information from the eye to the brain along the nerve after considerable information processing and synaptic transmission between various cell types within the retina.

In another experiment, the researchers severed rodents» optic nerves — an act ordinarily lethal to RGCs, whose outgoing fibers, called axons, constitute the optic nerve.

(E) Retinal ganglion cell axons exit the eye as the optic nerve (white arrow), pass under the brain and out of view then reappear on the contralateral side (arrowhead).

We observed YFP - labeled processes exiting the induced eye at the optic nerve head that followed the expected trajectory of RGC axons to their tectal targets (Figure 4E).

The reprogrammed cells formed all seven classes of retinal cells normally found in the eyes, including the retinal ganglion cells, which have axons (optic nerves) that extend to the brain.

We are using these new tools to image the structural features of individual cells, such as the cell body and the axons of the cells, which are long fibers that extend from each neuron, together forming the optic nerve that transmits visual information to the brain.

We will leverage state - of - the - art bioinformatic and biological approaches for investigating how these factors interact in combination to regulate axon growth during RGC development and test the potential of such factors for regenerating RGC axons in a rodent model of optic nerve injury.

Here the axons going down the optic nerve, across the optic chiasm, and into the expected targets in the brain: the lateral geniculate and the superior colliculus.

GenSight's treatment is for people with damaged photoreceptor cells but intact ganglion cells; it inserts the gene into the ganglion cells, whose axons form the basis of the optic nerve.

We're focused on glaucoma and it has to do with a set of very surprising findings in a region that we know is critical for axon loss in glaucoma, which is the optic nerve head.

In this study, we will examine whether glial cells and certain proteins secreted from these cells influence axon regeneration and guidance in the optic nerve in adult mice.

Identifying factors that regulate directional growth of regenerating RGC axons to their targets will provide invaluable information on developing future therapies to repair degenerated optic nerve following glaucoma.

Understanding the role of glial cells in glaucoma as well as what happens to the optic nerve where the retinal nerve axons leave the eye may present new therapeutic targets and even potential biomarkers of glaucoma.

Vision loss from glaucoma occurs when axons in the optic nerve become damaged and can no longer carry visual information to the brain.

Right now all therapy for glaucoma is directed at lowering eye pressure, but the idea that we could develop therapies and test them in people that really target the retinal ganglion cells and the axon fibers going into the optic nerve — that, I think, is the most exciting new frontier for the premise of restoring vision and protecting vision in glaucoma.

Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model Soto, I., Oglesby, E., Buckingham, B.P., Son, J.L., Roberson, E.D., Steele, M.R., Inman, D.M., Vetter, M.L., Horner, P.J. & Marsh - Armstrong, N. (2008) Journal of Neuroscience, 28:548 - 61.

The researchers also reported that eliminating one of those genes, Rab27, led to regeneration of axons in the optic nerve or spinal cord of mice.