We seek in this proposal to determine whether a particular type of imaging is capable of assessing and reporting on the integrity of sub-microscopic structures within
optic nerve fibers at an early stage of damage preceding their complete degeneration and loss from the eye.
We seek to determine whether a particular type of imaging, known as «polarization - sensitive» imaging, is capable of reporting on the integrity of sub-microscopic structures within
optic nerve fibers at an early stage of damage from glaucoma, preceding their complete degeneration and loss from the eye.
In fact, so much of the progress that we're making in laboratories, including mine, is on developing neuroprotective therapies that can protect the retina from degeneration, regenerate
optic nerve fibers all the way back to their targets in the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nerve.
(CNN)- Christopher Lukasik was building shelves when a metal rod hit his eye, tearing about a third of
his optic nerve fibers and leaving everybody from his doctors to his family wondering whether he would ever see again.
Not exact matches
And like other retinal ganglion cells in the eye, the ipRGCs grow long
fibers that snake out to join the
optic nerve.
Anatomical investigations have shown, however, that there are many more receptor cells in the retina than there are
fibers in the
optic nerve.
All of us daily lose some of the 2 million
nerve fibers in our
optic nerve and we can lose 50 - 60 percent of them without it really affecting our vision, Liu says.
«We looked at the
optic nerve and saw normal myelination,» Mukherjee said, referring to the fatty white sheathing wrapped around axons, the
nerve fibers that allow information transmission over distances to proceed efficiently and rapidly.
In another experiment, the researchers severed rodents»
optic nerves — an act ordinarily lethal to RGCs, whose outgoing
fibers, called axons, constitute the
optic nerve.
Millions of
nerve fibers running from the ganglion cells dive through the eye's «blind spot» and form the
optic nerve that carries impulses to the brain.
We are using these new tools to image the structural features of individual cells, such as the cell body and the axons of the cells, which are long
fibers that extend from each neuron, together forming the
optic nerve that transmits visual information to the brain.
Of course, visual field testing, looking at the
optic nerve,
optic nerve atrophy,
nerve fiber layer thinning, using optical coherence tomography, but the real question is can we back that up significantly and be able to tell whether the patient sitting right there in the chair is in trouble?
We've devised ways to test patients using new imaging technologies to measure the health of their retinal ganglion cells and of their
fibers entering the
optic nerve.
Replacing rods and cones is challenging, because these cells have to establish connections with
nerve fibers that feed signals into the
optic nerve, which sends those signals to the brain to interpret.
In the early stages of glaucoma, there is a failure of transport of important scaffolding material, nutrients and individual
fibers in the
optic nerve.
The Nobel Prize - winning physiologist Haldan Hartline discovered that the
optic nerve of Limulus polyphemus could be frayed into thin bundles, and then further split apart until he had a single
fiber on which to run his experiments.
Right now all therapy for glaucoma is directed at lowering eye pressure, but the idea that we could develop therapies and test them in people that really target the retinal ganglion cells and the axon
fibers going into the
optic nerve — that, I think, is the most exciting new frontier for the premise of restoring vision and protecting vision in glaucoma.