(A) Postprandial TG clearance in fasted mutant and WT mice treated for 4 weeks with control or ApoC - III ASO after
an oral gavage of corn oil (250 μl).
At 1 pm, they were given a 200 - μl bolus of corn oil (Sigma - Aldrich) by
oral gavage.
Mice were fasted for 5 hours and subjected to
oral gavage (200 μl / mouse) with 5 μCi [11,12 - 3H] retinol in corn oil (Sigma - Aldrich).
To measure the impact of ApoC - III suppression on the clearance of dietary TGs in the circulation, we administered a bolus of corn oil by
oral gavage to mice treated with ApoC - III ASO and sampled their blood at various time points.
«A single dose of D+Q (D: 5 mg kg − 1 body weight and Q: 50 mg kg − 1 by
oral gavage here and in the following studies), a drug ratio that was most effective in senescent MEFs (data not shown), reduced SA - βgal + cells (Fig.
Not exact matches
BAZ2 - ICR showed very high solubility (25 mM in D2O), a measured log D of 1.05, high stability in mouse microsomes, and permeation in the CaCo - 2 model and thus a suitable profile for
oral and intravenous
gavage.
Oral chronic
gavage with galanin in diabetic mice increases insulin sensitivity, which is associated with an improvement of several metabolic parameters such as glucose tolerance, fasting blood glucose, and insulin.
Repetitive treatment with the ApoC - III ASO progressively decreased plasma TGs (Supplemental Figure 6B) and increased TG clearance after
oral corn oil
gavage (Supplemental Figure 6C) or after injection of [3H] triolein - labeled Liposyn particles (Figure 8E).