Many of the greatest studies on
oral hyaluronic acid, for knee pain or skincare, tested Hyabest, which is a patented form of sodium hyaluronate made by a Japanese company.
In the early 20th century, hyaluronic acid was believed to be biologically inert, simply a structural molecule in the skin, while as recently as the 1990s, there were doubts over whether
oral hyaluronic acid achieved anything.