Thirteen - week
oral toxicity study of branched - chain amino acids in rats.
Argentyn 23 also recently completed a murine Acute
Oral Toxicity Study (LD50) with Covance Laboratories, Inc., (ref: 24742 -0-800).
Not exact matches
The
study tested a lower dose of the
oral multi-targeted tyrosine kinase inhibitor sunitinib than in previous trials, where
toxicity proved too much of a problem.
Acute
toxicity studies showed no
oral toxicity of J147 in mice at the maximum testable dose of 2 gm / kg and other safety tests including hERG, CYP450 inhibition and Ames were also negative which further supports the safety of J147.
Oral acute
toxicity studies in rats indicated an LD50 greater than 4,640 mg / kg.