Sentences with word «orexin»

With additional controls, the Stanford group proved that the release of orexin from the lateral hypothalamus was what drove this behavior.

Eating lots of sugar reduces the activity of what are called orexin cells.

It's also been shown that amino acids, such as those found in meat, have the ability to simulate orexin cells which would make you feel more alert and awake.

Here about 750 cells produce orexin (also known as hypocretin), a hormone that promotes wakefulness.

In obese mice, activation of this receptor stimulates orexin A release.

Interestingly, sleep deprivation markedly increased the buildup of Aβ in the brain of a mouse model of AD; whereas a drug that block orexin actions markedly decreased the buildup of Aβ.

Research has shown lower orexin levels can contribute to drowsiness and inactivity, the first step to a good night's sleep.

How they work: The medications hinder the activity of the chemical orexin in the brain, which may turn off wakefulness and promote sleep.

A new compound that inhibits the activity of alertness - promoting brain peptides called orexins shows promise as a sleeping pill, according to tests in people and animals.

We will be assessing the effects of aging and orexin signaling on Aβ and other neural proteins both acutely and chronically.

Although sugar gets a bad rap, it can have some beneficial effects when it comes to sleep due to its effect on orexin.

The team from the Royal Alexandra Hospital for Children is currently working on a new study to determine why orexin is low in some infants and not others.

Interestingly, those who suffer from narcolepsy, a disease in which people are excessively tired and may spontaneously fall asleep during the day, also lack orexin due to a breakdown in the brain cells that produce it.

The team deprived rats of food, says Yanagisawa, «and lo and behold [orexin] was up - regulated.»

In normal - weight mice, activation of this receptor decreases orexin A release.

Polymorphisms in hypocretin / orexin pathway genes and narcolepsy.

The quick boost in glucose levels from these naturally sweet foods reduces orexin, a neurotransmitter that triggers the brain to wake you up and get more food!

The Clock mutants were also shown to exhibit reduced overall expression levels and a blunted diurnal rhythm of orexin mRNA, a hypothalamic neuropeptide involved in energy regulation (2).

New sleep aids block the activity of brain peptides called orexins, which play a role in addiction

In people who have narcolepsy with cataplexy, there is a loss of neurons that produce orexins.

Egg whites stimulate orexin, a neurochemical released during REM sleep that controls wakefulness.

Knowing this link between SIDS and low levels of orexin, newborns can be tested to find out their individual risk factors.

The orexins aren't the first peptides found to stimulate hunger, but because their receptors are known, researchers can start looking for drugs that either mimic or block their appetite - enhancing effects.

Yanagisawa and his UT Southwestern colleagues, working with researchers at SmithKline Beecham Pharmaceuticals, discovered the peptides, which they call orexins (from the Greek word for appetite), during a routine search for peptides that activate so - called «orphan receptors.»

And it's particularly good news that orexins are found only in the lateral hypothalamus, says appetite researcher Jeffrey Friedman of Rockefeller University in New York City.

Mutations in the orexin receptors are associated with narcolepsy, a chronic sleep disorder.

As a result of the manipulation, almost all the orexin neurons, but none of the other intermingled neurons, carried ChR2 photoreceptors.

Furthermore, blue light via an optical fiber precisely and reliably generated waves of spikes in the orexin cells.

His group has found that orexin - producing neurons are activated when mice eat a high - fat diet, but ghrelin is required to go from simple feeding to binge - eating the fatty food, the researchers report in the October Psychoneuroendocrinology.

The switch involves receptors that trigger or inhibit the release of the orexin A peptide, which stimulates the appetite, among other behaviors.

Activating these CB1 receptors decreases inhibition of the orexin neurons, increasing orexin A release and food consumption.

«Before, activating this receptor inhibited the secretion of orexin; now it promotes it.

Using mice, this study found that in obesity, CB1 cannabinoid receptors become enriched on the nerve terminals that normally inhibit orexin neuron activity, and the orexin neurons produce more of the endocannabinoids to activate these receptors.

Obesity causes leptin levels to be chronically high, making brain cells less sensitive to its actions, which contributes to the molecular switch that leads to the overproduction of orexin.

Mazindol mimics the effects of a brain chemical called orexin, which modulates wakefulness and appetite.

Hypocretin (orexin) facilitates reward by attenuating the anti-reward effects of its co-transmitter dynorphin.

We also found that a protein involved in modulating the sleep - wake cycle called orexin / hypocretin also influences Aβ levels in the brain.

The goal of our studies is to understand the role of the orexin (Orx / Hcrt) system in cocaine and alcohol seeking.

Sleep, aging, and Alzheimer's disease (AD): Regulation of AD - associated proteins by sleep, aging, and orexin

The mutation is in a gene that encodes a neuropeptide called hypocretin (orexin), which is involved in the control of wakefulness.