Research has shown lower
orexin levels can contribute to drowsiness and inactivity, the first step to a good night's sleep.
Not exact matches
Obesity causes leptin
levels to be chronically high, making brain cells less sensitive to its actions, which contributes to the molecular switch that leads to the overproduction of
orexin.
We also found that a protein involved in modulating the sleep - wake cycle called
orexin / hypocretin also influences Aβ
levels in the brain.
It's also been shown that
levels of the hormones leptin, ghrelin, cortisol and
orexin — all of which are involved in appetite or eating — are affected by lack of sleep.
The quick boost in glucose
levels from these naturally sweet foods reduces
orexin, a neurotransmitter that triggers the brain to wake you up and get more food!
For example,
orexin / hypocretin
levels increase during sleep loss (39) and
orexin / hypocretin neurons are an important component of sleep — wakefulness and feeding neural systems (40, 41).
The Clock mutants were also shown to exhibit reduced overall expression
levels and a blunted diurnal rhythm of
orexin mRNA, a hypothalamic neuropeptide involved in energy regulation (2).