Sentences with phrase «organ models on»

Creating organ models on a microscale has been greatly facilitated by microfluidics, a technology developed in the 1990s that uses micropumps, valves and finely etched channels to manipulate the movement of fluids through a chip.

«With Teresa Woodruff's research using Draper's human organ system platform, we have a compelling demonstration of the importance of a microenvironment that permits cells to function in vitro as they would in vivo, and the power of being able to interconnect organ models on a platform and operate them in a stable and precise manner for weeks to months,» said Jeffrey T. Borenstein, a biomedical engineer at Draper.

Not exact matches

So right now, they focus on other applications, such as building precise three - dimensional models, drawn from CT scans, of actual patient organs and tissues that surgeons can use for pre-operative practice and training in the case of difficult surgeries.

Based on animal models, including a primate model, it is hypothesized that the cells remain unharmed in the digestive tract of the infant then enter the bloodstream, migrate to different organs, and there provide active immunity.54

Now, a team at the Wyss Institute for Biologically Inspired Engineering at Harvard University co-led by Wyss Institute Founding Director Donald Ingber, M.D., Ph.D., and Wyss Core Faculty member James Collins, Ph.D., has leveraged the Institute's proprietary human - organs - on - chips technology to microengineer a model of human intestinal inflammation and bacterial overgrowth in a human - gut - on - a-chip.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

Ingber and his colleagues are working on analogous models of other organs, too, including a beating heart and a gut capable of a peristaltic wave.

«If human organs on chips can be shown to be robust and consistently recapitulate complex human organ physiology and disease phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.

The US Defense Advanced Research Projects Agency (DARPA) is funding the integration of 10 individual organs - on - a-chip to create a miniature model of the human body.

We have been using cell culture models and zebrafish as an assay to determine the effects of BMP on signaling, but we also want to be able to understand what the effect of the mutation is in the tissue and organ systems.

Researchers can attach sensors to the organ models to give surgeons real - time feedback on how much force they can use during surgery without damaging the tissue.

Why rely on mouse brains to help us understand our most complex organ when you can grow a model of a human one?

A team of researchers from the Massachusetts General Hospital (MGH) Center for Engineering in Medicine (MGH - CEM) have created a «liver on a chip,» a model of liver tissue that replicates the metabolic variations found throughout the organ and more accurately reflects the distinctive patterns of liver damage caused by exposure to environmental toxins, including pharmaceutical overdose.

Working in mice that were put on high - fat diets to model diabetes, «we demonstrated that obesity increases the expression of pro-inflammatory genes in abdominal fat, but not in other organs such as the liver or muscle, nor in subcutaneous fat,» says Jongsoon Lee, PhD, Assistant Investigator in Joslin's Section on Pathophysiology and Molecular Pharmacology and Assistant Professor of Medicine at Harvard Medical School.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

IN ANY KIND OF TISSUE ENGINEERING — whether the aim is to create transplantable organs or miniature organ - on - a-chip models — researchers sometimes depend on stem cells that can adapt themselves to the purpose at hand.

While these examples illustrate the complexity possible in organ - on - a-chip design, Takayama, Griffith and others are also interested in models that take a more stripped - down approach to imitating organs and their afflictions.

Emulate's founders have spent years paving a path to widespread acceptance of organs - on - chips by both drug industry leaders and the FDA, whose trust in the models is essential for their success.

This technical article details multiple challenges involved in linking multiple organs on chips to create systems that realistically model human physiology.

BUT ORGANS ON CHIPS ARE N'T USEFUL ONLY as a way to create more realistic models of healthy, functioning organs; the miniature versions can also replicate what happens when things go ORGANS ON CHIPS ARE N'T USEFUL ONLY as a way to create more realistic models of healthy, functioning organs; the miniature versions can also replicate what happens when things go organs; the miniature versions can also replicate what happens when things go wrong.

Over the last few years, scientists have been able to recreate accurate models of human organs by embedding living tissue onto chips, allowing them to study the effects of drugs and diseases without testing on animals or humans.

The data generated with this model are consistent with clinical findings, and highlight the significant contribution of this Organ - on - Chip technology to recapitulate and even predict the risk for thrombotic events of novel drug candidates.

We seek outstanding postdoctoral applicants with expertise in respiratory cell biology and physiology and / or surface barrier (mucosal) inflammation to join an interdisciplinary team of biologists and engineers for the development of novel in vitro «organ - on - chip» microsystems technologies to study and model pulmonary disorders (Huh D et al..

Ingber prefers «organs - on - chips,» another modeling approach that lines microchips with human cells — or, more recently, human organoids.

In addition to her expertise in tumor biology and a broad network of connections with leading scientists and clinicians in cancer research and clinical oncology, Dr. Almog has extensive hands - on experience with a variety of techniques ranging from the molecular level (DNA, RNA and proteins) to tissue, organ and mouse models in cancer biology, as well as extensive experience in project management and program coordination.

In 2013, his team developed an organ - on - a-chip microfluidic culture device that modeled the human kidney's proximal tubule, which is anatomically connected to the glomerulus and salvages ions from urinary fluid.

This postdoctoral fellow is expected to develop and lead an interdisciplinary research project aimed at creating microengineered human «organ - on - chip» models and exploring their use for drug discovery applications.

Linking the differentiation process with organ - on - a-chip technology pioneered by his team, the researchers went on to engineer the first in vitro model of the human glomerulus, demonstrating effective and selective filtration of blood proteins and podocyte toxicity induced by a chemotherapy drug in vitro.

Researchers developed a 3D model of the female reproductive system using organ - on - a-chip technology.

The first mechanism (the neuromuscular model) is based on the so - called stretch reflex, which is also called the muscle spindle reflex or myotatic reflex, and on the Golgi tendon organ reflex (GTO reflex; Radliffe and Farentinos, 1999).

Effects of whole body vibration on the skeleton and other organ systems in man and animal models: What we know and what we need to know.

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As Russell P. Kramer, a Republican cheapskate clearly modeled on Ronald Reagan, Lemmon frequently compares his old opponent to a male sex organ.

The side structure of the old model was poor, and measures recorded on the driver dummy indicated that a person in a real - world crash of this severity could sustain rib fractures, internal organ injuries, and a fractured pelvis.

Each dinner includes muscle meats, organs and natural bones, based on the principles of the whole prey model.

The Feed Healthy campaign promotes the company's ALPHA Prey - model diet, which recognizes that all dogs and cats are natural carnivores and instinctively thrive on the essential nutrients from the whole animal — raw meat, bone and whole vital organs.