Sentences with phrase «organismal aging»

Whether cellular senescence contributes to organismal aging has been controversial.

Overall, these studies will progress our understanding on how organismal aging is an integrated process resulting from signaling events in muscle and other tissues.

The idea that shrinking telomeres play a role in organismal aging had been hyped in the media and by Geron's public relations division, she says.

Not exact matches

These experiments will help dissect how nutrient changes orchestrates changes in multiple tissues to modulate age - related decline in various organismal and tissue - specific functions.

This approach is rooted in the century - old concept of heterochronic parabiosis, whereby exposure of aged tissues to young factors can extend organismal lifespan and improve aged tissue function.

It has been postulated that aging is the consequence of an accelerated accumulation of somatic DNA mutations and that subsequent errors in the primary structure of proteins ultimately reach levels sufficient to affect organismal functions.

The aim of WICT is the removal from the organismal environment of accumulated cellular and intracellular damage present in the patient's endogenous cells, including telomere depletion, nuclear DNA damage and mutations, mitochondrial DNA damage and mutations, replicative senescence, functionally - deleterious age - related changes in gene expression and accumulated cellular and intracellular aggregates.