Sentences with phrase «organismal function»

It has been postulated that aging is the consequence of an accelerated accumulation of somatic DNA mutations and that subsequent errors in the primary structure of proteins ultimately reach levels sufficient to affect organismal functions.

Not exact matches

Although no functions could be assigned to three of the proteins, bioinformatics analysis suggested that the remainder are involved in a wide range of biological processes, including reproduction, cellular metabolic processes, multicellular organismal growth, developmental processes, growth, locomotion, response to stimuli, localization and biological regulation.

The research team led by Prof. Dr. Ingrid Lohmann of the Centre for Organismal Studies (COS) studied the function of a special developmental gene of the Hox gene family.

To fulfil the promise of stem cell therapy, it is important to discover the function of the respective stem cells and understand how they interact with their environment, that is, the surrounding cells and tissues,» explains Prof. Lohmann, who heads the Developmental Biology research group at the Centre for Organismal Studies (COS).

The Heidelberg researchers study the function and molecular structure of these «weapons systems» at the Centre for Organismal Studies.

These experiments will help dissect how nutrient changes orchestrates changes in multiple tissues to modulate age - related decline in various organismal and tissue - specific functions.

This approach is rooted in the century - old concept of heterochronic parabiosis, whereby exposure of aged tissues to young factors can extend organismal lifespan and improve aged tissue function.

We report a variety of biallelic effects on organismal phenotype attributable to combinations of recessive Xpd alleles, including the following: (i) the ability of homozygous lethal Xpd alleles to ameliorate a variety of disease symptoms when their essential basal transcription function is supplied by a different disease - causing allele, (ii) differential developmental and tissue - specific functions of distinct Xpd allele products, and (iii) interallelic complementation, a phenomenon rarely reported at clinically relevant loci in mammals.

RNA - based gene regulation is revealing itself as key to understanding cellular function, organismal development and homeostasis.

Our laboratory is focused on understanding how lipids contribute to membrane function and organismal fitness from synthetic protocells to microorganisms.

Computational Algorithms and Tools (Bruce Aronow, Section Editor): This section focuses on the generation of databases, analysis tools, or large scale analyses carried out from new or established datasets that generate hypotheses into the structure and function of physiological systems at the sub cellular or organismal level.

Predation risk has strong effects on organismal physiology that can cascade to impact ecosystem structure and function.

Relatively recent advances in organismal engineering have opened up new frontiers related to harnessing biosynthesis for the production of new materials with tailored functions that would be difficult to create using conventional synthetic techniques.