Sentences with phrase «organoid models from»

Due to the high efficiency of establishing organoid models from different tissues and diseases, such as cancer, organoid technology allows the generation of large living biobanks of tumor organoids that are amenable for middle - throughput drug screens and may allow personalized therapy design, as a complement to cell line and xenograft - based drug studies (7,19).

Not exact matches

One postdoc presents data on her efforts to develop an organoid model for small - cell lung cancer; another reports progress on culturing hormone - secreting organoids from human gut tissue.

Because organoids can be generated with high efficiency and speed from patient samples, they can serve as a personal cancer model that can guide clinical decision - making.

«For example, there is a huge amount of interest and excitement globally in growing cerebral organoids» — miniature brain - like organs that can be studied in laboratory experiments — «from stem cells to model human brain development and disease mechanisms.

The brain organoid, engineered from adult human skin cells, is the most complete human brain model yet developed, said Rene Anand, professor of biological chemistry and pharmacology at Ohio State.

Single - cell technologies will be applied to experimental model systems such as organoids, miniature organs grown in the petri dish from one or more cells.

To better understand this complex tissues and its functions — and the diseases that affect it — a multicenter team led by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital has released a census of the cells that make up the lining of the small intestine, using gene expression profiles of more than 53,000 individual cells from the mouse gut or gut organoid models.

For understanding the biology of gene - gene, gene - drug and gene - microenvironment interactions, a considerably broader range of in vitro and in vivo model systems is required — we are generating 1,000 organoid cultures from human cancers, characterising their genomes, functional dependencies and drug response, and we are expanding our in vivo models to study the interface between cancer and the immune system and microenvironment.

Organoids, or miniature organs, are a relatively new model system that has emerged from stem cell research and are making a big impact.

These epithelial organoid cultures are genetically and phenotypically extremely stable, allowing transplantation of the cultured offspring of a single stem cell, as well as disease modeling by growing organoids directly from diseased patient tissues (45).

The experts explain that many of the state - of - the - art technologies are required to tease out relevant information from model systems, whether these be organoids or «classical animal models such as the fruit fly, zebra fish or mouse,» adds Milán.

Experiments on pancreas organoids — models that are essentially balls of cells sampled from the pancreas of healthy people and pancreatic cancer patients — showed that lowering antioxidant levels within cancerous pancreas cells, or cells on the way to becoming cancerous, kills them.