Sentences with phrase «organs on chips»

BUT ORGANS ON CHIPS ARE N'T USEFUL ONLY as a way to create more realistic models of healthy, functioning organs; the miniature versions can also replicate what happens when things go wrong.

ORGANS ON CHIPS EMERGED from efforts to engineer whole organs for replacement.

To gain widespread adoption in the academic and commercial research communities for personalized drug testing and other uses — and perhaps one day to replace millions of lab animals — organs on chips will need to be affordable and easy to use.

Tiny «Organ Chips» Promise Big Boost to Testing of Food, Drugs: Scientists at the FDA hope to use «organs on chips» to study how certain chemicals from foods, cosmetics and supplements affect organs in the body.

And as newer versions of organs on chips get better at mimicking the function of real organs — a kidney's ability to filter waste from the bloodstream, for example — the devices themselves may find their way into humans, replacing or augmenting underperforming organs.

This technical article details multiple challenges involved in linking multiple organs on chips to create systems that realistically model human physiology.

Human «organs on chips» could be linked to make the ideal guinea pig, revolutionising the way drugs are tested and cancer is treated

«If human organs on chips can be shown to be robust and consistently recapitulate complex human organ physiology and disease phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.

Other researchers are building what some call «organs on a chip.»

These «organs on a chip,» as they are called, are typically glass slides coated with human cells that have been configured to mimic a particular tissue or interface between tissues.

This accessible review article provides a comprehensive overview of the history of organs on a chip and describes major directions in research.?

These «organs on a chip» — so called for their resemblance to silicon computer microchips — look nothing like the body parts they're meant to replicate.

Not exact matches

«We hope this will expand the use of organs - on - chips in a variety of contexts, including drug screening and drug toxicity studies,» adds Khademhosseini.

Now, a team at the Wyss Institute for Biologically Inspired Engineering at Harvard University co-led by Wyss Institute Founding Director Donald Ingber, M.D., Ph.D., and Wyss Core Faculty member James Collins, Ph.D., has leveraged the Institute's proprietary human - organs - on - chips technology to microengineer a model of human intestinal inflammation and bacterial overgrowth in a human - gut - on - a-chip.

The lung - on - a-chip was the first human organ to be scaled down to chip form.

A research team led by scientists from Brigham and Women's Hospital has developed a novel technology platform that enables the continuous and automated monitoring of so - called «organs - on - chips» — tiny devices that incorporate living cells to mimic the biology of bona fide human organs.

Scientists have long experimented with organs - on - chips: tiny representations of human organs, such as lungs, hearts and intestines, made from cells embedded on plastic about the size of a computer memory stick.

«New technology platform propels the use of «organs - on - chips».»

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

The inclusion of a patient's «genetic fingerprint» demonstrates another benefit of organs - on - chips: a source for precision medicine and personalized health by testing how an individual would respond to a treatment, Hamilton said.

This flexibility allows the organs - on - chips to be used in many different laboratories and spurs «democratization» of the technology, she said.

The organs - on - chips can then be used to test the efficacy of drug treatments on a particular organ.

Hamilton announced the newest organ - on - chip innovation, which recreates an intestinal lining using patient - derived stem cells, created through a partnership between Emulate and Cedars - Sinai Board of Governors Regenerative Medicine Institute.

Despite the complexity of the biology, the simplicity of the chip's engineering allows it to serve as a footprint for diverse types of organs - on - chips, Hamilton said.

Additionally, using organs - on - chips for testing avoids unnecessarily exposing patients to drug treatments that might be ineffective or have harmful side effects, Urban added.

The Wyss team's TEER - measuring Organ Chip design is published in Lab on a Chip.

The most advanced qubits are circuits made of superconducting metal, and to control or read out a qubit, researchers make it interact with a microwave resonator — typically a strip of metal on the qubit chip or a finger - size cavity surrounding it — which rings with microwave photons like an organ pipe rings with sound.

«More realistic and accurate organs - on - chips.»

To control or read out a superconducting qubit, researchers make it interact with a microwave resonator — typically a strip of metal on the qubit chip or a finger - size cavity surrounding it — which rings with microwave photons the way an organ pipe rings with sound.

«Body on a chip» could improve drug evaluation: Human tissue samples linked by microfluidic channels replicate interactions of multiple organs..»

In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channel.

A team of researchers from the Massachusetts General Hospital (MGH) Center for Engineering in Medicine (MGH - CEM) have created a «liver on a chip,» a model of liver tissue that replicates the metabolic variations found throughout the organ and more accurately reflects the distinctive patterns of liver damage caused by exposure to environmental toxins, including pharmaceutical overdose.

The engineered cell culture enabled interaction between three cell types of the airways and reproduced their physiological interfaces — becoming essentially an «organ - on - chip.»

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

Emulate's founders have spent years paving a path to widespread acceptance of organs - on - chips by both drug industry leaders and the FDA, whose trust in the models is essential for their success.

Creating organ models on a microscale has been greatly facilitated by microfluidics, a technology developed in the 1990s that uses micropumps, valves and finely etched channels to manipulate the movement of fluids through a chip.

Our plans include creating individually tailored Organ - Chips with a patient's own cells to allow biology to be predicted on a person - by - person basis.

How «Organs on a Chip» Will Revolutionize Medicine: Scientists can now do research on live human organs without petri dishes or animal testing.

«Engineering Challenges for Instrumenting and Controlling Integrated Organ - on - Chip Systems,» by John Wikswo et al., IEEE Transactions on Biomedical Engineering, March 2013.

Building on that project, the researchers have now designed a machine that smokes cigarettes in a very human - like manner, and hooked it up to organs - on - chips lined by human lung small airway cells so the smoke interacts with these cells in a realistic way.

Over the last few years, scientists have been able to recreate accurate models of human organs by embedding living tissue onto chips, allowing them to study the effects of drugs and diseases without testing on animals or humans.

One of the pioneers in the field of Organs - on - Chips technology, Prof. Dongeun (Dan) Huh of the University of Pennsylvania, will moderate the panel, which is titled, «Emulating Human Biology: Organ - Chips for Drug Development and Personalized Medicine.»

Engraftment of bioengineered vascular networks Juan Melero - Martin, Boston Children's Hospital Organ specific vascular niche - derived angiocrine factors induce specification and self - renewal of stem cells Shahin Rafii, Weill Medical College at Cornell A perfused Blood - Brain Barrier on a chip Christopher C.W. Hughes, University of California, Irvine

The data generated with this model are consistent with clinical findings, and highlight the significant contribution of this Organ - on - Chip technology to recapitulate and even predict the risk for thrombotic events of novel drug candidates.

We seek outstanding postdoctoral applicants with expertise in respiratory cell biology and physiology and / or surface barrier (mucosal) inflammation to join an interdisciplinary team of biologists and engineers for the development of novel in vitro «organ - on - chip» microsystems technologies to study and model pulmonary disorders (Huh D et al..

Ingber prefers «organs - on - chips,» another modeling approach that lines microchips with human cells — or, more recently, human organoids.

This postdoctoral fellow is expected to develop and lead an interdisciplinary research project aimed at creating microengineered human «organ - on - chip» models and exploring their use for drug discovery applications.

Researchers are also beginning to «fuse» different organoid types to approximate the kinds of linked systems Ingber achieves with organs - on - chips.

Organs - on - chips, for example, re-create organ systems in tiny detail and can be used to test drugs and understand how the body works.

As the Forum noted on its blog, our Organ - Chips «could be constructed using stem cells derived from the patients themselves, and then tests could be run to identify individualized therapies that are more likely to succeed.»