The UT Southwestern group had previously used CRISPR - Cas9,
the original gene - editing system, to correct the Duchenne defect in a mouse model of the disease and in human cells.
And when sepsis does develop, they are three times more likely to survive than those with
the original gene.
That group also concluded that the increased risk of sepsis caused the defective variant to replace
the original gene.
The extra copy, free of the burden of performing
the original gene's biological duties, can accumulate changes through random mutations.
Pruitt says RNA «templates» derived from
the original gene and stored in the gametes are the best candidates for reverting the mutant gene to its original state.
Vaccinated chickens proved immune to infection by NDV and the H5N2 flu strain that provided
the original gene.
But while the X chromosome has remained large throughout evolution, with about 2000 genes, the Y chromosome lost most of its genetic material early in its evolution; it now retains less than 100 of
those original genes.
They found that chickens with the Muffs and beard trait had three duplicated regions of chromosome 27, inserted next to one of
the original gene regions.
The UT Southwestern group had previously used CRISPR - Cas9,
the original gene - editing system, to correct the dystrophin defect in a mouse model of the disease and in human cells.
Although
the original gene drive remains in the organisms, it's inactive.
Hopefully it will lead moviegoers to seek out
the original Gene Rodenberry TV show with Nimoy, Shatner, and George Takei.
In this, «Beyond» is closer to
the original Gene Roddenberry TV incarnation than most of its filmic predecessors.