Although
the original gene drive remains in the organisms, it's inactive.
Not exact matches
The idea of «reversal
drives,» which would overwrite mutated
genes with the
original sequence, often arises as a promising solution to
gene drives gone wild.
Only two women in the study had cancer -
driving mutations — both in an estrogen receptor
gene called ESR1 — in their recurrent tumors not seen in the
original.
Genomic changes can be reversed with subsequent
gene drives, though the cassette encoding the guide RNAs and possibly cas9 will remain and any ecological changes resulting from the
original genomic alteration will not necessarily be reversed.