Sentences with phrase «original tumor»

Breast cancer research and treatment have long focused on a patient's original tumor as a guide to preventing relapse; however, research suggests that some recurrent cancers are different from the primary tumor and may respond better to different therapies.

But genetic similarities between metastasized and original tumors suggest that multiple cells move together to remote sites.

Metastasis is tһe process wһегеby cancer cells spread frоm thе site оf thе original tumor tо onе oг mогe otһеr places іn tһe body.

When a tumor is treated with chemo, the tumor may disappear but some cancer stem cells have the ability to survive, and they have the potential to regenerate the original tumor and spread the cancer elsewhere.

Not only did the original tumors not recur in the breast, but metastatic tumors in the lungs — far away from the site of drug delivery — were eliminated as well.

Once they have consumed all the oxygen and nutrients in the original tumor site, the cancer cells travel to other parts of the body (metastasize) to find more nourishment.

When the dendritic cells are activated, they train T cells — their allies in the adaptive arm of the immune system — to attack cancer cells anywhere in the body, whether at the site of the original tumor or distant metastases.

When researchers injected fresh breast cancer cells in the side opposite the original tumor site, the disease didn't recur in any of the mice, as the cancer was rejected by the immune system's memory.

, and 10 genes that were associated with the amount of time it took the melanoma to move from the original tumor to the rest of the body.

If this is true, we might be able to identify these subsets and target them before these cells leave their original tumor sites and invade distant organs,» says Prof. Alon.

The scientists conducted the research using see - through zebra fish so that they could see how the cancer cells moved and expanded from the original tumor.

The researchers watched through a microscope as cells spread from the original tumor.

Dr. Jochen Maurer and his research group were able to cultivate several cancer stem cell lines from triple receptor - negative breast cancer that are excellent representations of the original tumors they isolated from the patients.

«When cancer comes back, it's genetically very similar to the original tumor but often with additional mutations that may give cancer cells new strategies to survive attack by whatever drugs are thrown at them.

Most of the mutations that drive recurrent tumors when they pop up elsewhere in the body were present in the original tumor, geneticist Elaine Mardis reported May 9 at the Biology of Genomes meeting.

A lot needs to go right for a cancer cell to successfully leave the site of its original tumor, travel in the bloodstream, enter a distant organ and begin to colonize it.

Because cancer that comes back and spreads after initial treatment is often deadlier than the original tumors, researchers thought most of the mutations in recurrent tumors happened after they spread.

In addition to potentially improving screening tests, the team believes their approach may someday help doctors control CTC - induced metastasis, which the researchers say can be far more lethal than the original tumor.

The traditional method of culturing tumor cells produces a single layer of cells that behave much differently from the original tumor.

The protein, hnRNPM, helps launch a cascade of events that enables breast cancer cells to break away from the original tumor, penetrate the blood stream, invade another part of the body and form a new nodule of that tumor.

It is well established that melanoma cells can spread through the blood to accumulate and form new tumors (metastases) in other parts of the body away from the original tumor.

So cancer researchers have developed methods for culturing three - dimensional tumor organoids that mimic the behavior of the original tumors so they can study how they grow.

Semenza says his team will continue its mouse studies to see if metastasis — the spread of cancer from the original tumor — is affected by the low oxygen / ALKBH5 / NANOG relationship too.

The new «tumor in a dish» method begins by taking the cancerous tissue removed during surgery or biopsy, cutting it up into small pieces and putting them in a special collagen gel that maintains them as «organoids» that retain the three - dimensional structure of the original tumor and include supporting cells from the tumor's environment.

«Being able to understand what came from the original tumor and what happened only in the metastases is key to improving treatment.

The researchers collected images depicting metastases where breast cancer had spread beyond the original tumors.

Cancer cells kill most often by crawling away from their original tumors to later re-root in vital parts of the body in a process called metastasis.

The treatment's effect on the original tumor was less dramatic, but still impressive: The combination of Listeria and radiation shrank the tumor by 64 %, and Listeria alone by about 20 % compared with saline - treated mice.

Without the genome sequence of Lacks» healthy cells or that of her original tumor, it is difficult to trace the origin of these alterations.

Potential uses Having been replicating in labs around the world for six decades, HeLa cells have also accrued errors not present in the original tumor DNA.

«The comparison showed that the Uppsala cell line was genetically identical with the original tumor whereas the U87MG cell line from ATCC had a different, unknown origin.

When the cell line was established in the 1960s, material from the original tumor was saved as thin sections on microscope slides.

This is essential if one wants to claim that the cells, and thereby the research results, are true representatives of the original tumor.

Now a team of UCLA researchers has discovered that a subset of tumor cells that don't produce the protein CA125, a biomarker used to test for ovarian cancer, has an enhanced ability to repair their DNA and resist programmed cell death — which allows the cells to evade the drug and live long enough to regrow the original tumor.

It is not easy to determine whether metastasis began early or late in the development of the primary tumor or whether individual metastatic sites were seeded directly from the original tumor or from an intermediate site.

Among the patients: 13 had a recurrence of cancer; nine had cancer spread from the original tumor to distant organs or distant lymph nodes.

Most cancer deaths are not due to primary tumors, but to secondary tumors in vital organs, such as the lungs or brain, caused by cells moving from the original tumor to other places in the body.

Of this latter group, none developed disease that spread beyond the original tumor into other organs but instead died of a secondary condition associated with locally progressive pancreas cancer.

This tumor specific immunity showed the potential of blocking the growth of the original tumor as well as eliminating small tumor deposits that can cause the cancer to spread.

«The original tumor seldom kills; poor prognosis is usually due to metastases as they spread to new tissues and organs.»

These cells are thought to break off from the original tumor and circulate in the blood, and may be a sign of an aggressive tumor.

The cells contain different proteins than the original tumor, so research is ongoing to unlock the secrets of these elusive cells.

Are these simply passenger mutations that arose from a surviving subclone from the original tumor, or are they key drivers of metastasis and tumor growth?

«Circulating tumor cells (CTCs) have been shed by the original tumor and entered the bloodstream — they can then form into new tumors if they lodge in distant tissue,» Wang says.

By day 60, the average tumor volume in mice treated with tamoxifen plus CDB4124 was 70 percent lower than the original tumors.

Metastasis is a dangerous phenomenon in which cancer cells separate from the original tumor, move into the bloodstream or lymphatic system, anchor in a distant tissue or organ, and begin a new tumor.

The ability of the tumor cells to metastasize locally within the brain is a significant clinical problem, which causes the disease to recur even after the original tumor is surgically removed.

But recurrence of the original tumor has remained the major cause of treatment failure.