Co-developed a method for determining
orthologous genes in prokaryotes that can differentiate close paralogs using gene neighborhood context.
Not exact matches
Positive selection
in the human genome inferred from human — chimp — mouse
orthologous gene alignments Clark, A. G., S. Glanowski, R. Nielsen, P. Thomas et al. 2003.
Positive selection
in the human genome inferred from human — chimp — mouse
orthologous gene alignments.
For example, Bsl1 itself was highly increased
in bsl1 - 1 mutants (corrected P = 0.003), as was a
gene encoding a BR C - 6 oxidase
orthologous to brassinosteroid deficient1 (brd1) from maize (Makarevitch et al., 2012) and rice (Hong et al., 2002)(SvBrd1; Sevir.9 G171700).
The new
genes, however, also include 119
genes that are 1 - 1
orthologous to
genes in P. vivax.
Rapidly diverging short
genes, even when they are evolutionarily
orthologous to
genes in other species, may be nearly impossible to classify as such.
Indeed, key aspects of most human disorders can be modeled
in experimentally tractable organisms through the analysis of
orthologous genes and pathways, using the genetic, biochemical and cell biological toolboxes that have been developed
in each model organism.
Of these, 126
genes were
orthologous to protein - coding
genes in the human genome (hereafter, human BC susceptibility
genes, hBCSGs), 70 % of which are previously reported cancer - associated
genes, and ∼ 16 % are known BC suppressor
genes.
RESULTS: Transcription of the MAOA
gene in rhesus monkeys is modulated by an
orthologous polymorphism (rhMAOA - LPR)
in its upstream regulatory region.