Sentences with phrase «oseltamivir mutations»

While adamantane resistance mutations appeared readily, it took 15 - 38 years after FDA approval to emerge, but emerged 3 times, whereas, the less spontaneous oseltamivir mutations took at most 7 years, serving as a public health cautionary tail.

Not exact matches

The His274 → Tyr274 (H274Y) mutation confers oseltamivir resistance on N1 influenza neuraminidase but had long been thought to compromise viral fitness.

The evolution of oseltamivir resistance was therefore enabled by «permissive» mutations that allowed the virus to tolerate subsequent occurrences of H274Y.

They describe virus strains with mutations known to confer high resistance to oseltamivir, which they isolated from a 13 - year old girl and a 35 - year old woman killed by H5N1.

But about 2 years ago, a seasonal strain appeared whose fitness is not diminished by the mutation — perhaps because other mutations compensate for it ---- which explains why that strain has spread so fast, even in countries that use little oseltamivir.

The virus with this mutation remains sensitive to the antiviral drugs, oseltamivir and zanamivir, and studies show that currently available pandemic vaccines confer protection.